个人科研网厅 | | 帮助
首都医科大学宣武医院知识库
高级检索
当前位置： 首页 > 详情页

Emerging epigenetic insights into aging mechanisms and interventions

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Zeming Wu[1,2,3] * ; Weiqi Zhang[2,4,5,6] ; Jing Qu[2,3,4,7] ; Guang-Hui Liu[1,2,3,4,8,9] ;
机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2] Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [3] Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [4]University of Chinese Academy of Sciences, Beijing 100049, China [5] China National Center for Bioinformation, Beijing 100101, China [6]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China [7]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [8] Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China [9]Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
出处：
DOI： 10.1016/j.tips.2023.12.002
ISSN：

摘要：
Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although still an evolving field with much to explore, it has rapidly gained significance by providing valuable insights into the mechanisms of aging and potential therapeutic opportunities for age-related diseases. Recent years have witnessed remarkable strides in our understanding of the epigenetic landscape of aging, encompassing pivotal elements, such as DNA methylation, histone modifications, RNA modifications, and noncoding (nc) RNAs. Here, we review the latest discoveries that shed light on new epigenetic mechanisms and critical targets for predicting and intervening in aging and related disorders. Furthermore, we explore burgeoning interventions and exemplary clinical trials explicitly designed to foster healthy aging, while contemplating the potential ramifications of epigenetic influences.Copyright © 2023 Elsevier Ltd. All rights reserved.

基金：
National Natural Science Foundation of China (81921006, 82125011, 92149301, and 32100937), the National Key Re search and Development Program of China (2022YFA1103700, 2022YFA1103800, 2020YFA0804000, 2020YFA0112200, and 2021YFF1201000), the National Natural Science Foundation of China (92168201, 91949209, 92049304, 92049116, 32121001, 82192863, 82361148130, and 82361148131), CAS Project for Young Scientists in Basic Research (YSBR-076 and YSBR-012), Youth Innovation Promotion Association of CAS (E1CAZW0401), New Cornerstone Science Foundation through the XPLORER PRIZE (2021-1045), Young Elite Scientists Sponsorship Program by CAST (2023QNRC001), and CAS Special Research Assistant (SRA) Program.
语种：
外文
高被引：
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 医学
小类 | 1 区 药学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 药学
JCR分区：
出版当年[2022]版：
Q1 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2] Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [3] Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China
通讯作者：
通讯机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2] Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [3] Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [4]University of Chinese Academy of Sciences, Beijing 100049, China [5] China National Center for Bioinformation, Beijing 100101, China [6]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China [7]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [8] Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China [9]Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Zeming Wu,Weiqi Zhang,Jing Qu,et al.Emerging epigenetic insights into aging mechanisms and interventions[J].TRENDS IN PHARMACOLOGICAL SCIENCES.2024,45(2):157-172.doi:10.1016/j.tips.2023.12.002.
APA：
Zeming Wu,Weiqi Zhang,Jing Qu&Guang-Hui Liu.(2024).Emerging epigenetic insights into aging mechanisms and interventions.TRENDS IN PHARMACOLOGICAL SCIENCES,45,(2)
MLA：
Zeming Wu,et al."Emerging epigenetic insights into aging mechanisms and interventions".TRENDS IN PHARMACOLOGICAL SCIENCES 45..2(2024):157-172

资源点击量：17316 今日访问量：1 总访问量：931 更新日期：2025-06-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持：重庆聚合科技有限公司 地址：北京市西城区长椿街45号宣武医院