详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Genetic susceptibility modifies the association of long-term air pollution exposure on Parkinson's disease

45| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China. [2]Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China. [3]Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, 200040, China. [4]Department of Neurology, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing, China. [5]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China. [6]Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China. [7]Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, 200040, China. [8]Fudan ISTBI-ZJNU Algorithm Centre for Brain-Inspired Intelligence, Zhejiang Normal University, Jinhua, 321004, China. [9]MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200032, China. [10]Zhangjiang Fudan International Innovation Center, Shanghai, 200433, China.

出处：

DOI：

ISSN：

摘要：

Inconsistent findings exist regarding the potential association between polluted air and Parkinson's disease (PD), with unclear insights into the role of inherited sensitivity. This study sought to explore the potential link between various air pollutants and PD risk, investigating whether genetic susceptibility modulates these associations. The population-based study involved 312,009 initially PD-free participants with complete genotyping data. Annual mean concentrations of PM2.5, PM10, NO2, and NOx were estimated, and a polygenic risk score (PRS) was computed to assess individual genetic risks for PD. Cox proportional risk models were employed to calculate hazard ratios (HR) and 95% confidence intervals (CI) for the associations between ambient air pollutants, genetic risk, and incident PD. Over a median 12.07-year follow-up, 2356 PD cases (0.76%) were observed. Compared to the lowest quartile of air pollution, the highest quartiles of NO2 and PM10 pollution showed HRs and 95% CIs of 1.247 (1.089-1.427) and 1.201 (1.052-1.373) for PD incidence, respectively. Each 10 μg/m3 increase in NO2 and PM10 yielded elevated HRs and 95% CIs for PD of 1.089 (1.026-1.155) and 1.363 (1.043-1.782), respectively. Individuals with significant genetic and PM10 exposure risks had the highest PD development risk (HR: 2.748, 95% CI: 2.145-3.520). Similarly, those with substantial genetic and NO2 exposure risks were over twice as likely to develop PD compared to minimal-risk counterparts (HR: 2.414, 95% CI: 1.912-3.048). Findings suggest that exposure to air contaminants heightens PD risk, particularly in individuals genetically predisposed to high susceptibility.© 2024. The Author(s).

基金：

语种：

高被引：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 1 区医学

小类 | 1 区神经科学

最新[2025]版：

大类 | 1 区

医学

小类 | 2 区神经科学

JCR分区：

出版当年[2022]版：

Q1 NEUROSCIENCES

最新[2023]版：

Q1 NEUROSCIENCES

影响因子： 6.7 最新[2023版] 7.3 最新五年平均 8.7 出版当年[2022版] 9.1 出版当年五年平均 9.304 出版前一年[2021版] 6.7 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

Genetic susceptibility modifies the association of long-term air pollution exposure on Parkinson's disease $(function () { $("[data-toggle='tooltip']").tooltip(); });

文献详情

Genetic susceptibility modifies the association of long-term air pollution exposure on Parkinson's disease