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Neutrophil extracellular traps mediated by platelet microvesicles promote thrombosis and brain injury in acute ischemic stroke

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收录情况： ◇ SCIE

作者：
Gao Xin[1,2] * ; Zhao Xinyi[3,4] * ; Li Jiacheng[4] * ; Liu Chang[4] * ; Li Wenqiang[5] ; Zhao Junjie[6] ; Li Zhixi[4] ; Wang Nan[1,2] ; Wang Fang[1,2] ; Dong Jiawei[1,2] ; Yan Xiuwei[1,2] ; Zhang Jiheng[1,2] ; Hu Xueyan[1] ; Jin Jiaqi[7] ; Mang Ge[3,4] ; Ma Ruishuang[8,9] ; Hu Shaoshan[1,2] ;
机构： [1]Department of Neurosurgery, Cancer Center, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China [2]Department of Neurosurgery, The Second Afliated Hospital of Harbin Medical University, Harbin, China [3]Department of Cardiology, The Second Afliated Hospital of Harbin Medical University, Harbin, China [4]The Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin, Heilongjiang Province, China [5]Department of Vascular Surgery, Jinshan Hospital of Fudan University, Shanghai, China [6]Department of General Surgery, Changsha Fourth Hospital, Changsha, China [7]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [8]Department of Radiotherapy and Chemotherapy, The First Afliated Hospital of Ningbo University, Ningbo, China [9]Department of Radiotherapy and Chemotherapy, Ningbo First Hospital of Ningbo, Ningbo 315000, China
出处：
DOI： 10.1186/s12964-023-01379-8
ISSN：

关键词： Neutrophil extracellular traps HMGB1 Platelet Microvesicles Thrombosis Stroke

摘要：
Neutrophil extracellular traps (NETs) have been implicated in thrombotic diseases. There is no definitive explanation for how NETs form during acute ischemic strokes (AIS). The purpose of our study was to investigate the potential mechanism and role of NETs formation in the AIS process.As well as 45 healthy subjects, 45 patients with AIS had ELISA tests performed to detect NET markers. Expression of high-mobility group box 1 (HMGB1) on platelet microvesicles (PMVs) was analyzed by flow cytometry in healthy subjects and AIS patients' blood samples. We established middle cerebral artery occlusion (MCAO) mice model to elucidate the interaction between PMPs and NETs.A significant elevation in NET markers was found in patient plasma in AIS patients, and neutrophils generated more NETs from patients' neutrophils. HMGB1 expression was upregulated on PMVs from AIS patients and induced NET formation. NETs enhanced Procoagulant activity (PCA) through tissue factor and via platelet activation. Targeting lactadherin in genetical and in pharmacology could regulate the formation of NETs in MCAO model.NETs mediated by PMVs derived HMGB1 exacerbate thrombosis and brain injury in AIS. Video Abstract.© 2024. The Author(s).

基金：
National Natural Science Foundation of Zhejiang Province (grant nos. Y23H160056), Youth Research Start-up Program of Jinshan Hospital of Fudan University (JYQN-JC-202108), Shanghai Municipal Health and Construction Commission scientifc Research Program (20214Y0365), the Excellent Scientifc Research Team Project of the First Afliated Hospital of Jiamusi University (grant no. 202301), the Natural Science Foundation of Changsha City (kq2202026), the Natural Science Foundation of Hunan Province (2022JJ40516) and China National Postdoctoral Program for Innovative Talents (BX20230238).
语种：
外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 生物学
小类 | 2 区 细胞生物学
最新[2023]版：
大类 | 2 区 生物学
小类 | 2 区 细胞生物学
JCR分区：
出版当年[2022]版：
Q1 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Neurosurgery, Cancer Center, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China [2]Department of Neurosurgery, The Second Afliated Hospital of Harbin Medical University, Harbin, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurosurgery, Cancer Center, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China [2]Department of Neurosurgery, The Second Afliated Hospital of Harbin Medical University, Harbin, China [3]Department of Cardiology, The Second Afliated Hospital of Harbin Medical University, Harbin, China [4]The Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin, Heilongjiang Province, China [8]Department of Radiotherapy and Chemotherapy, The First Afliated Hospital of Ningbo University, Ningbo, China [9]Department of Radiotherapy and Chemotherapy, Ningbo First Hospital of Ningbo, Ningbo 315000, China
推荐引用方式(GB/T 7714)：
Gao Xin,Zhao Xinyi,Li Jiacheng,et al.Neutrophil extracellular traps mediated by platelet microvesicles promote thrombosis and brain injury in acute ischemic stroke[J].CELL COMMUNICATION AND SIGNALING.2024,22(1):50.doi:10.1186/s12964-023-01379-8.
APA：
Gao Xin,Zhao Xinyi,Li Jiacheng,Liu Chang,Li Wenqiang...&Hu Shaoshan.(2024).Neutrophil extracellular traps mediated by platelet microvesicles promote thrombosis and brain injury in acute ischemic stroke.CELL COMMUNICATION AND SIGNALING,22,(1)
MLA：
Gao Xin,et al."Neutrophil extracellular traps mediated by platelet microvesicles promote thrombosis and brain injury in acute ischemic stroke".CELL COMMUNICATION AND SIGNALING 22..1(2024):50

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