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Comparison of 18F-FDG PET and arterial spin labeling MRI in evaluating Alzheimer's disease and amnestic mild cognitive impairment using integrated PET/MR

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Bi Sheng[1,2,3] * ; Yan Shaozhen[1,2,3] ; Chen Zhigeng[1,2,3] ; Cui Bixiao[1,2,3] ; Shan Yi[1,2,3] ; Yang Hongwei[1,2,3] ; Qi Zhigang[1,2,3] ; Zhao Zhilian[1,2,3] ; Han Ying[4] ; Lu Jie[1,2,3] ;
机构： [1]Department of Radiology & Nuclear Medicine, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053, China. [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China. [3]Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China. [4]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
出处：
DOI： 10.1186/s13550-024-01068-8
ISSN：

关键词： Alzheimer’s disease Mild cognitive impairment Arterial spin labeling MRI 18F-FDG PET Integrated PET/MR

摘要：
Developing biomarkers for early stage AD patients is crucial. Glucose metabolism measured by 18F-FDG PET is the most common biomarker for evaluating cellular energy metabolism to diagnose AD. Arterial spin labeling (ASL) MRI can potentially provide comparable diagnostic information to 18F-FDG PET in patients with neurodegenerative disorders. However, the conclusions about the diagnostic performance of AD are still controversial between 18F-FDG PET and ASL. This study aims to compare quantitative cerebral blood flow (CBF) and glucose metabolism measured by 18F-FDG PET diagnostic values in patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) using integrated PET/MR.Analyses revealed overlapping between decreased regional rCBF and 18F-FDG PET SUVR in patients with AD compared with NC participants in the bilateral parietotemporal regions, frontal cortex, and cingulate cortex. Compared with NC participants, patients with aMCI exclusively demonstrated lower 18F-FDG PET SUVR in the bilateral temporal cortex, insula cortex, and inferior frontal cortex. Comparison of the rCBF in patients with aMCI and NC participants revealed no significant difference (P > 0.05). The ROC analysis of rCBF in the meta-ROI could diagnose patients with AD (AUC, 0.87) but not aMCI (AUC, 0.61). The specificity of diagnosing aMCI has been improved to 75.56% when combining rCBF and 18F-FDG PET SUVR.ASL could detect similar aberrant patterns of abnormalities compared to 18F-FDG PET in patients with AD compared with NC participants but not in aMCI. The diagnostic efficiency of 18F-FDG-PET for AD and aMCI patients remained higher to ASL. Our findings support that applying 18F-FDG PET may be preferable for diagnosing AD and aMCI.© 2024. The Author(s).

基金：
National Natural Science Foundation of China (Grant No. 82102010), Beijing Brain Initiative from Beijing Municipal Science & Technology Commission (Z201100005520018), and Beijing Municipal Administration of Hospitals Incubating Program (QML20230810).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 核医学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 核医学
JCR分区：
出版当年[2022]版：
Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Radiology & Nuclear Medicine, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053, China. [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China. [3]Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China.
通讯作者：
通讯机构： [1]Department of Radiology & Nuclear Medicine, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053, China. [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China. [3]Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China.
推荐引用方式(GB/T 7714)：
Bi Sheng,Yan Shaozhen,Chen Zhigeng,et al.Comparison of 18F-FDG PET and arterial spin labeling MRI in evaluating Alzheimer's disease and amnestic mild cognitive impairment using integrated PET/MR[J].EJNMMI RESEARCH.2024,14(1):9.doi:10.1186/s13550-024-01068-8.
APA：
Bi Sheng,Yan Shaozhen,Chen Zhigeng,Cui Bixiao,Shan Yi...&Lu Jie.(2024).Comparison of 18F-FDG PET and arterial spin labeling MRI in evaluating Alzheimer's disease and amnestic mild cognitive impairment using integrated PET/MR.EJNMMI RESEARCH,14,(1)
MLA：
Bi Sheng,et al."Comparison of 18F-FDG PET and arterial spin labeling MRI in evaluating Alzheimer's disease and amnestic mild cognitive impairment using integrated PET/MR".EJNMMI RESEARCH 14..1(2024):9

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