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Identification of molecular markers for predicting the severity of heart failure after AMI: An Olink precision proteomic study

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机构： [1]Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [2]Department of Geriatrics, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China. [3]Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

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关键词： Heart failure Biomarkers Acute myocardial infarction Proteomic

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Acute myocardial infarction (AMI) still has a high incidence of varying degrees of heart failure (HF). The aim of this study is to identify new molecular markers for predicting the severity of HF after AMI.We analyzed demographic indicators, past medical history, clinical indicators, major adverse cardiac events (MACEs) and molecular markers in patients with different Killip classifications after AMI. Olink proteomics was used to explore new molecular markers for predicting different severity of HF after AMI.Neutrophil count was the independent risk factors for in-hospital MACEs. Nineteen differentially expressed proteins (DEPs) increased significantly with increasing Killip classification. Five DEPs were also found to have an AUC (95 % CI) value greater than 0.8: GDF-15, NT-pro BNP, TNF-R2, TNF-R1 and TFF3.Neutrophil count, GDF-15, TNF-R2, TNF-R1 and TFF3 were closely related to the Killip classification of HF after AMI, which suggests that the inflammatory response plays an important role in the severity of HF after AMI and that regulating inflammation might become a new target for controlling HF.Copyright © 2024 Elsevier B.V. All rights reserved.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区医学实验技术

最新[2023]版：

大类 | 3 区医学

小类 | 3 区医学实验技术

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Q1 MEDICAL LABORATORY TECHNOLOGY

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Q2 MEDICAL LABORATORY TECHNOLOGY

影响因子： 3.2 最新[2023版] 3.7 最新五年平均 5 出版当年[2022版] 4.2 出版当年五年平均 6.315 出版前一年[2021版] 3.2 出版后一年[2023版]

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第一作者机构： [1]Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

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