个人科研网厅 | | 帮助
首都医科大学宣武医院知识库
高级检索
当前位置： 首页 > 详情页

Brain-derived extracellular vesicles mediate systemic coagulopathy and inflammation after traumatic brain injury

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Li Fanjian[1,2,3,4,5] * ; Li Lei[1,2,3,4,5] * ; Peng Ruilong[1,2,3,4,5] * ; Liu Chuan[1,2,3,4] * ; Liu Xiao[1,2,4,5] * ; Liu Yafan[1,2,3,4,5] ; Wang Cong[1,2,3,4,5] ; Xu Jianye[1,2,3,4,5] ; Zhang Qiaoling[1,2,3,4,5] ; Yang Guili[1,2,3,4,5] ; Li Ying[1,2,4,5] ; Chen FangLian[1,2,4,5] ; Li Shenghui[1,2,4,5] ; Cui Weiyun[1,2,4,5] ; Liu Li[1,2,4,5] ; Xu Xin[6] ; Zhang Shu[1,2,4,5,*1] ; Zhao Zilong[1,2,4,5,*1] ; Zhang Jianning[1,2,4,5,*1] ;
机构： [1]Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China [2]Tianjin Neurological Institute, Tianjin, China [3]Graduate School, Tianjin Medical University, Tianjin, China [4]Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin, China [5]Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, China [6]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, China
出处：
DOI： 10.1016/j.intimp.2024.111674
ISSN：

关键词： Traumatic brain injury Extracellular vesicles Coagulopathy Inflammation Lactadherin

摘要：
Traumatic brain injury (TBI) can induce systemic coagulopathy and inflammation, thereby increasing the risk of mortality and disability. However, the mechanism causing systemic coagulopathy and inflammation following TBI remains unclear. In prior research, we discovered that brain-derived extracellular vesicles (BDEVs), originating from the injured brain, can activate the coagulation cascade and inflammatory cells. In this study, we primarily investigated how BDEVs affect systemic coagulopathy and inflammation in peripheral circulation. The results of cytokines and coagulation function indicated that BDEVs can lead to systemic coagulopathy and inflammation by influencing inflammatory factors and chemokines within 24 h. Furthermore, according to flow cytometry and blood cell counter results, we found that BDEVs induced changes in the blood count such as a reduced number of platelets and leukocytes and an increased percentage of neutrophils, macrophages, activated platelets, circulating platelet-EVs, and leukocyte-derived EVs. We also discovered that eliminating circulating BDEVs with lactadherin helped improve coagulopathy and inflammation, relieved blood cell dysfunction, and decreased the circulating platelet-EVs and leukocyte-derived EVs. Our research provides a novel viewpoint and potential mechanism of TBI-associated secondary damage.Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.

基金：
This research was supported by the National Natural Science Foundation of China (grant82022020, 81971176, 82371376, 82001317, 81901525 and 81930031) and the Beijing Hospitals Authority Youth Programmer (grant QML20230801)
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
JCR分区：
出版当年[2022]版：
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China [2]Tianjin Neurological Institute, Tianjin, China [3]Graduate School, Tianjin Medical University, Tianjin, China [4]Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin, China [5]Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China [2]Tianjin Neurological Institute, Tianjin, China [4]Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin, China [5]Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, China [*1]Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
推荐引用方式(GB/T 7714)：
Li Fanjian,Li Lei,Peng Ruilong,et al.Brain-derived extracellular vesicles mediate systemic coagulopathy and inflammation after traumatic brain injury[J].International Immunopharmacology.2024,130:111674.doi:10.1016/j.intimp.2024.111674.
APA：
Li Fanjian,Li Lei,Peng Ruilong,Liu Chuan,Liu Xiao...&Zhang Jianning.(2024).Brain-derived extracellular vesicles mediate systemic coagulopathy and inflammation after traumatic brain injury.International Immunopharmacology,130,
MLA：
Li Fanjian,et al."Brain-derived extracellular vesicles mediate systemic coagulopathy and inflammation after traumatic brain injury".International Immunopharmacology 130.(2024):111674

相关文献

[1]Diverse Activities of von Willebrand Factor in Traumatic Brain Injury and Associated Coagulopathy. [2]Circulating extracellular vesicles from patients with traumatic brain injury induce cerebrovascular endothelial dysfunction [3]Dissemination of brain inflammation in traumatic brain injury [4]创伤性脑损伤诱发的凝血功能障碍研究进展 [5]Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats. [6]Exploring Nasal Drop Therapy With Small Extracellular Vesicles for ALS [7]The AMPAR Antagonist Perampanel Attenuates Traumatic Brain Injury Through Anti-Oxidative and Anti-Inflammatory Activity [8]Plasma extracellular vesicles proteomics in meningioma patients [9]中老年人群急性单发性创伤性颅脑损伤相关性凝血病的临床分析 [10]Hydrogen mitigates brain injury by prompting NEDD4-CX43- mediated mitophagy in traumatic brain injury

资源点击量：16399 今日访问量：0 总访问量：869 更新日期：2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持：重庆聚合科技有限公司 地址：北京市西城区长椿街45号宣武医院