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Efficacy of transcranial photobiomodulation in the treatment for major depressive disorder: A TMS-EEG and pilot study

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机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Neuromodulation, Beijing, China. [3]Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China. [4]Center for sleep and consciousness disorders, Beijing Institute for Brain Disorders, Beijing, China. [5]Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China. [6]Hebei Hospital of Xuanwu Hospital, Capital Medical University, Shijiazhuang, China. [7]Neuromedical Technology Innovation Center of Hebei Province, Shijiazhuang, China.

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Major depressive disorder (MDD) was a prevalent mental condition that may be accompanied by decreased excitability of left frontal pole (FP) and abnormal brain connections. An 820 nm tPBM can induce an increase in stimulated cortical excitability. The purpose of our study was to establish how clinical symptoms and time-varying brain network connectivity of MDD were affected by transcranial photobiomodulation (tPBM).A total of 11 patients with MDD received 820 nm tPBM targeting the left FP for 14 consecutive days. The severity of symptoms was evaluated by neuropsychological assessments at baseline, after treatment, 4-week and 8-week follow-up; 8-min transcranial magnetic stimulation combined electroencephalography (TMS-EEG) was performed for five healthy controls and five patients with MDD before and after treatment, and time-varying EEG network was analyzed using the adaptive-directed transfer function.All of scales scores in the 11 patients decreased significantly after 14-day tPBM (p < .01) and remained at 8-week follow-up. The time-varying brain network analysis suggested that the brain regions with enhanced connection information outflow in MDD became gradually more similar to healthy controls after treatment.This study showed that tPBM of the left FP could improve symptoms of patients with MDD and normalize the abnormal network connections.© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区皮肤病学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区皮肤病学

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出版当年[2022]版：

Q2 DERMATOLOGY

最新[2023]版：

Q2 DERMATOLOGY

影响因子： 2.5 最新[2023版] 3 最新五年平均 2.6 出版当年[2022版] 3 出版当年五年平均 3.254 出版前一年[2021版] 2.5 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Neuromodulation, Beijing, China. [3]Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.

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通讯作者：

通讯机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Neuromodulation, Beijing, China. [3]Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China. [4]Center for sleep and consciousness disorders, Beijing Institute for Brain Disorders, Beijing, China. [5]Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China. [6]Hebei Hospital of Xuanwu Hospital, Capital Medical University, Shijiazhuang, China. [7]Neuromedical Technology Innovation Center of Hebei Province, Shijiazhuang, China. [*1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

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