详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder

39| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：梯队期刊 ◇ ESCI

作者：

机构： [1]Songjiang Hospital and Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [2]Institute of Neuroscience and Brain Diseases, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China. [3]Division of Neuropsychiatry and Psychosomatics, Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China. [4]Electroconvulsive Therapy, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA. [5]Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. [6]Institute of Sleep and Consciousness Disorders, Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China. [7]Institute of Special Medical Sciences, School of Forensic Medicine, Shanxi Medical University, Taiyuan, Shanxi, China.

出处：

DOI：

ISSN：

摘要：

Although 15 mA transcranial alternating current stimulation (tACS) has a therapeutic effect on depression, the activations of brain structures in humans accounting for this tACS configuration remain largely unknown.To investigate which intracranial brain structures are engaged in the tACS at 77.5 Hz and 15 mA, delivered via the forehead and the mastoid electrodes in the human brain.Actual human head models were built using the magnetic resonance imagings of eight outpatient volunteers with drug-naïve, first-episode major depressive disorder and then used to perform the electric field distributions with SimNIBS software.The electric field distributions of the sagittal, coronal and axial planes showed that the bilateral frontal lobes, bilateral temporal lobes, hippocampus, cingulate, hypothalamus, thalamus, amygdala, cerebellum and brainstem were visibly stimulated by the 15 mA tACS procedure.Brain-wide activation, including the cortex, subcortical structures, cerebellum and brainstem, is involved in the 15 mA tACS intervention for first-episode major depressive disorder. Our results indicate that the simultaneous involvement of multiple brain regions is a possible mechanism for its effectiveness in reducing depressive symptoms.© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 3 区医学

小类 | 4 区精神病学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区精神病学

JCR分区：

出版当年[2022]版：

无

最新[2023]版：

Q1 PSYCHIATRY

影响因子： 5.3 最新[2023版] 6.2 最新五年平均 11.9 出版当年[2022版] 0 出版当年五年平均 0 出版前一年[2021版] 5.3 出版后一年[2023版]

第一作者：

第一作者机构： [1]Songjiang Hospital and Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [2]Institute of Neuroscience and Brain Diseases, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.

通讯作者：

通讯机构： [3]Division of Neuropsychiatry and Psychosomatics, Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China. [6]Institute of Sleep and Consciousness Disorders, Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China. [7]Institute of Special Medical Sciences, School of Forensic Medicine, Shanxi Medical University, Taiyuan, Shanxi, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：