机构：[1]Academy for Advanced Interdisciplinary Studies (AAIS), Peking University, Beijing 100871, China.[2]Chinese Institute for Brain Research, Beijing, Beijing 102206, China.[3]Department of Chemistry and School of Pharmacy, University of Wisconsin-Madison, Wisconsin 53705, USA.[4]School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.[5]State Key Laboratory of Proteomics, National Center for Protein Sciences-Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing 102206, China.[6]College of Life Sciences, Nankai University, Tianjin, 300071, China.[7]Beijing Normal University, State Key Laboratory of Cognitive Neuroscience and Learning &IDG/McGovern Institute for Brain Research, Beijing 100875, China.[8]Department of Laboratory Medicine, Changzheng Hospital, Naval Medical University, Shanghai 200003, China.[9]Changping Laboratory, Beijing 102206, China.[10]School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.[11]Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.浙江大学医学院附属第一医院[12]National Institute of Biological Sciences, Beijing, 102206, China.[13]Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, Beijing 100053, China.神经科系统神经外科首都医科大学宣武医院[14]Allen Institute for Brain Science, Seattle, Washington 98109, USA.[15]Medical Imaging laboratory of Core Facility Center, Capital Medical University, Beijing 100054, China.[16]Eugene McDermott Center for Human Growth and Development, Department of Bioinformatics, School of Public Health, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
The subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown. To explore its function, we compared transcriptomes of SCO and non-SCO brain regions and found three genes, Sspo, Car3, and Spdef, that are highly expressed in the SCO. Mouse strains expressing Cre recombinase from endogenous promoter/enhancer elements of these genes were used to genetically ablate SCO cells during embryonic development, resulting in severe hydrocephalus and defects in neuronal migration and development of neuronal axons and dendrites. Unbiased peptidomic analysis revealed enrichment of three SCO-derived peptides, namely thymosin beta 4, thymosin beta 10, and NP24, and their reintroduction into SCO-ablated brain ventricles substantially rescued developmental defects. Together, these data identify a critical role for the SCO in brain development.
语种：
外文
PubmedID：
第一作者：
第一作者机构：[1]Academy for Advanced Interdisciplinary Studies (AAIS), Peking University, Beijing 100871, China.[2]Chinese Institute for Brain Research, Beijing, Beijing 102206, China.
通讯作者：
通讯机构：[2]Chinese Institute for Brain Research, Beijing, Beijing 102206, China.[9]Changping Laboratory, Beijing 102206, China.[10]School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.[13]Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Zhang Tingting,Ai Daosheng,Wei Pingli,et al.The subcommissural organ regulates brain development via secreted peptides[J].Biorxiv : The Preprint Server For Biology.2024,doi:10.1101/2024.03.30.587415.
APA：
Zhang Tingting,Ai Daosheng,Wei Pingli,Xu Ying,Bi Zhanying...&Ge Woo-Ping.(2024).The subcommissural organ regulates brain development via secreted peptides.Biorxiv : The Preprint Server For Biology,,
MLA：
Zhang Tingting,et al."The subcommissural organ regulates brain development via secreted peptides".Biorxiv : The Preprint Server For Biology .(2024)
