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Vascular Endothelial Growth Factor and Ischemic Stroke Risk: A Mendelian Randomization Study

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Zhang Xiao[1,2,3] * ; Hu Xinzhi[4] * ; Fang Shiyuan[4,5] * ; Li Jiayao[1,3] ; Liu Zhichao[2] ; Xie Weidun[6] ; Xu Ran[1,3] ; Dmytriw Adam A[7] ; Yang Kun[8] ; Ma Yan[1,3] ; Jiao Liqun[1,3,9] ; Wang Tao[1,3] ;
机构： [1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China [2]Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK [3]China International Neuroscience Institute (ChinaINI), 45 Changchun Street, Beijing 100053, China [4]Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China [5]Department of Neurology, Peking Union Medical College Hospital, Beijing 100730, China [6]Department of Computer Science, City University of Hong Kong, Kowloon 999077, Hong Kong SAR [7]Neuroendovascular Program, Massachusetts General Hospital, Boston, MA 02114, USA [8]Department of Neurosurgery, Tai’an Central Hospital, 29 Longtan Road, Tai’an 271000, Shandong, China [9]Department of Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District Beijing 100053, China
出处：
DOI： 10.1007/s40120-024-00601-0
ISSN：

关键词： Vascular endothelial growth factor Ischemic stroke Causal association Mendelian randomization Stroke prevention Causal link

摘要：
Previous studies have reported controversial relationships between circulating vascular endothelial growth factors (VEGF) and ischemic stroke (IS). This study aims to demonstrate the causal effect between VEGF and IS using Mendelian randomization (MR).Summary statistics data from two large-scale genome-wide association studies (GWAS) for 16,112 patients with measured VEGF levels and 40,585 patients with IS were downloaded from public databases and included in this study. A published calculator was adopted for MR power calculation. The primary outcome was any ischemic stroke, and the secondary outcomes were large-artery stroke, cardioembolic stroke, and small-vessel stroke. We used the inverse variance-weighted (IVW) method for primary analysis, supplemented by MR-Egger regression and the weighted median method.Nine SNPs were included to represent serum VEGF levels. The IVW method revealed no strong causal association between VEGF and any ischemic stroke (odds ratio [OR] 1.01, 95% CI 0.99-1.04, p = 0.39), cardioembolic stroke (OR 1.04, 95% CI 0.97-1.12, p = 0.28), large-artery stroke (OR 1.02, 95% CI 0.95-1.09, p = 0.62), and small-vessel stroke (OR 0.98, 95% CI 0.91-1.04, p = 0.46). These findings remained robust in sensitivity analyses. MR-Egger regression suggested no horizontal pleiotropy.This Mendelian randomization study found no relationship between genetically predisposed serum VEGF levels and risks of IS or its subtypes.© 2024. The Author(s).

基金：
This work was supported by the Beijing Scientific and Technologic Project [grant number Z201100005520019], the National Natural Science Foundation of China [grant number 82171303], Beijing Hospitals Authority’s Ascent Plan [grant number DFL20220702], the National Natural Science Foundation of China [grant number 82301468], Beijing Municipal Administration of Hospitals Incubating Program [grant number PX2021034]
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外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 临床神经病学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 临床神经病学
JCR分区：
出版当年[2022]版：
Q2 CLINICAL NEUROLOGY
最新[2023]版：
Q1 CLINICAL NEUROLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China [2]Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK [3]China International Neuroscience Institute (ChinaINI), 45 Changchun Street, Beijing 100053, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China [3]China International Neuroscience Institute (ChinaINI), 45 Changchun Street, Beijing 100053, China [9]Department of Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District Beijing 100053, China
推荐引用方式(GB/T 7714)：
Zhang Xiao,Hu Xinzhi,Fang Shiyuan,et al.Vascular Endothelial Growth Factor and Ischemic Stroke Risk: A Mendelian Randomization Study[J].NEUROLOGY AND THERAPY.2024,13(3):727-737.doi:10.1007/s40120-024-00601-0.
APA：
Zhang Xiao,Hu Xinzhi,Fang Shiyuan,Li Jiayao,Liu Zhichao...&Wang Tao.(2024).Vascular Endothelial Growth Factor and Ischemic Stroke Risk: A Mendelian Randomization Study.NEUROLOGY AND THERAPY,13,(3)
MLA：
Zhang Xiao,et al."Vascular Endothelial Growth Factor and Ischemic Stroke Risk: A Mendelian Randomization Study".NEUROLOGY AND THERAPY 13..3(2024):727-737

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