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The subcommissural organ regulates brain development via secreted peptides

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机构： [1]Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China [2]Chinese Institute for Brain Research, Beijing, China [3]Department of Chemistry and School of Pharmacy, University of Wisconsin–Madison, Madison, WI, USA [4]School of Basic Medical Sciences, Anhui Medical University, Hefei, China [5]State Key Laboratory of Proteomics, National Center for Protein Sciences-Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, China [6]College of Life Sciences, Nankai University, Tianjin, China [7]State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China [8]Department of Laboratory Medicine, Changzheng Hospital, Naval Medical University, Shanghai, China [9]Changping Laboratory, Beijing, China [10]School of Basic Medical Sciences, Capital Medical University, Beijing, China [11]Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China [12]National Institute of Biological Sciences, Beijing, China [13]Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, Beijing, China [14]Allen Institute for Brain Science, Seattle, WA, USA [15]Medical Imaging laboratory of Core Facility Center, Capital Medical University, Beijing, China [16]Eugene McDermott Center for Human Growth and Development, Department of Bioinformatics, School of Public Health, UT Southwestern Medical Center, Dallas, TX, USA

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The subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown. Here, to explore its function, we compared transcriptomes of SCO and non-SCO brain regions and found three genes, Sspo, Car3 and Spdef, that are highly expressed in the SCO. Mouse strains expressing Cre recombinase from endogenous promoter/enhancer elements of these genes were used to genetically ablate SCO cells during embryonic development, resulting in severe hydrocephalus and defects in neuronal migration and development of neuronal axons and dendrites. Unbiased peptidomic analysis revealed enrichment of three SCO-derived peptides, namely, thymosin beta 4, thymosin beta 10 and NP24, and their reintroduction into SCO-ablated brain ventricles substantially rescued developmental defects. Together, these data identify a critical role for the SCO in brain development. The subcommissural organ (SCO) is a gland in the brain, and relatively little is known about its function. Zhang et al. genetically ablated SCO cells and observed severe hydrocephalus and neuronal defects. The reintroduction of SCO-derived peptides into SCO-ablated brain substantially rescued developmental defects.

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出版当年[2023]版：

大类 | 1 区

医学

小类 | 1 区神经科学

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区神经科学

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Q1 NEUROSCIENCES

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Q1 NEUROSCIENCES

影响因子： 21.3 最新[2023版] 25.7 最新五年平均 25 出版当年[2022版] 27.7 出版当年五年平均 28.771 出版前一年[2021版] 21.3 出版后一年[2023版]

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第一作者机构： [1]Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China [2]Chinese Institute for Brain Research, Beijing, China

通讯作者：

通讯机构： [2]Chinese Institute for Brain Research, Beijing, China [9]Changping Laboratory, Beijing, China [10]School of Basic Medical Sciences, Capital Medical University, Beijing, China [13]Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, Beijing, China

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