Recanalization of occluded vessels and timely reperfusion are the primary therapies for acute ischemic stroke (AIS), with endovascular thrombectomy proven as the most efective therapy for large-vessel recanalization and improved outcomes of AIS patients. However, despite a high recanalization rate of 90% or even higher, the rate of 3-month functional independence is approximately 50%, while mortality remains around 15% [1]. This mismatch between successful large-vessel recanalization and mediocre prognosis necessitates further investigation into the underlying mechanisms and the development of strategies. It has been suggested that the unsatisfactory prognosis could be attributed to the expansion of the ischemic core, failed revascularization or incomplete reperfusion, and secondary reperfusion injury.