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Alterations in cortical thickness and volumes of subcortical structures in pediatric patients with complete spinal cord injury

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收录情况： ◇ SCIE

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机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China. [3]Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. [4]Department of Medical Imaging, Affiliated Hospital of Hebei Engineering University, Handan, China. [5]Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. [6]Department of Rehabilitation Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.

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To study the changes in cortical thickness and subcortical gray matter structures in children with complete spinal cord injury (CSCI), reveal the possible causes of dysfunction beyond sensory motor dysfunction after CSCI, and provide a possible neural basis for corresponding functional intervention training.Thirty-seven pediatric CSCI patients and 34 age-, gender-matched healthy children as healthy controls (HCs) were recruited. The 3D high-resolution T1-weighted structural images of all subjects were obtained using a 3.0 Tesla MRI system. Statistical differences between pediatric CSCI patients and HCs in cortical thickness and volumes of subcortical gray matter structures were evaluated. Then, correlation analyses were performed to analyze the correlation between the imaging indicators and clinical characteristics.Compared with HCs, pediatric CSCI patients showed decreased cortical thickness in the right precentral gyrus, superior temporal gyrus, and posterior segment of the lateral sulcus, while increased cortical thickness in the right lingual gyrus and inferior occipital gyrus. The volume of the right thalamus in pediatric CSCI patients was significantly smaller than that in HCs. No significant correlation was found between the imaging indicators and the injury duration, sensory scores, and motor scores of pediatric CSCI patients.These findings demonstrated that the brain structural reorganizations of pediatric CSCI occurred not only in sensory motor areas but also in cognitive and visual related brain regions, which may suggest that the visual processing, cognitive abnormalities, and related early intervention therapy also deserve greater attention beyond sensory motor rehabilitation training in pediatric CSCI patients.© 2024 The Author(s). CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.

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出版当年[2023]版：

大类 | 1 区医学

小类 | 2 区神经科学 2 区药学

最新[2023]版：

大类 | 1 区医学

小类 | 2 区神经科学 2 区药学

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出版当年[2022]版：

Q1 NEUROSCIENCES Q1 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY Q1 NEUROSCIENCES

影响因子： 4.8 最新[2023版] 5.9 最新五年平均 5.5 出版当年[2022版] 6.2 出版当年五年平均 7.035 出版前一年[2021版] 4.8 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China.

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通讯作者：

通讯机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China. [4]Department of Medical Imaging, Affiliated Hospital of Hebei Engineering University, Handan, China. [*1]Department of Medical Imaging, Affiliated Hospital of Hebei Engineering University, No. 81 Congtai Road, Handan, Hebei, China. [*2]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, No. 45 Chang-chun St, Xicheng District, Beijing, China.

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