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Association between elevated systemic inflammatory markers and the risk of cognitive decline progression: a longitudinal study

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收录情况： ◇ SCIE

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机构： [1]Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, China. [2]Department of Neurology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, 7 Weiwu Street, Zhengzhou, 450000, China. chenchensjnk@163.com.

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关键词： Alzheimer’s disease Infammation Risk Cognition Dementia Vascular dementia

摘要：

Chronic systemic inflammation is linked to cognitive decline pathogenesis. This study investigates the association between systemic inflammation markers and cognitive decline progression in a clinical cohort.This prospective observational cohort study enrolled 295 participants. Cognitive decline progression was defined by an increase in clinical dementia rating (CDR) scores. The study examines the correlation between systemic inflammation markers, including systemic Inflammation Response Index (SIRI), systemic Immune-Inflammation Index (SII), prognostic Inflammatory and Nutritional Index (PIV), and cognitive impairment progression.The presence of the APOE 4 allele and diabetes mellitus was associated with elevated PIV levels (P < 0.05). Additionally, AD patients had the highest SII levels, indicating increased inflammation compared to individuals with MCI and SCD (P < 0.05). After a mean follow-up of 17 months, 117 patients (51.31%) experienced cognitive decline progression. AD diagnosis, CDR, and SII were significant predictors of cognitive decline progression (All P < 0.05).This study highlights the clinical significance of elevated systemic inflammation markers in identifying individuals at risk of cognitive decline. Addressing inflammation may offer a promising approach to improving cognitive health and mitigating age-related cognitive decline.© 2024. Fondazione Società Italiana di Neurologia.

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出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

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出版当年[2022]版：

Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

最新[2023]版：

Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 2.7 最新[2023版] 2.7 最新五年平均 3.3 出版当年[2022版] 3.2 出版当年五年平均 3.83 出版前一年[2021版] 2.7 出版后一年[2023版]

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第一作者机构： [1]Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, China.

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