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Estimating the prevalence and clinical causality of obstructive sleep apnea in paediatric narcolepsy patients

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机构: [1]Capital Med Univ, Xuanwu Hosp, Dept Neurol & Innovat Ctr Neurol Disorders, Natl Ctr Neurol Disorders, Beijing, Peoples R China [2]Zhengzhou Univ Peoples Hosp, Henan Prov Peoples Hosp, Dept Neurol, 7 Weiwu St, Zhengzhou 450000, Peoples R China
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关键词: Obstructive sleep apnea Narcolepsy Prevalence Mendelian randomization Causal relationships

摘要:
Background Numerous risk factors in paediatric narcolepsy may predispose them to obstructive sleep apnea (OSA). The concurrent presence of OSA in these patients might lead to underdiagnosing narcolepsy. This research investigates the prevalence and potential causality between OSA and paediatric narcolepsy. Methods A case-control study coupled with a two-sample Mendelian randomization (MR) analysis was employed to explore the prevalence and causal link between paediatric narcolepsy and OSA risk. Results The case-control study revealed that paediatric narcolepsy patients are at an increased risk of OSA, with an Odds ratio (OR) of 4.87 (95% CI: 2.20-10.71; P < 0.001). The inverse-variance weighted (IVW) model further suggests a potential causal link between narcolepsy and OSA (IVW OR: 4.671, 95% CI: 1.925-11.290; P < 0.001). Additionally, sensitivity analysis confirmed these findings' reliability. Conclusion The findings highlight an elevated prevalence and genetic susceptibility to OSA among paediatric narcolepsy patients, underscoring the necessity for clinical screening of OSA. Continued research is essential to clarify the pathogenic mechanisms and develop potential treatments.

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出版当年[2023]版:
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 呼吸系统
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 呼吸系统
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出版当年[2022]版:
Q3 CLINICAL NEUROLOGY Q3 RESPIRATORY SYSTEM
最新[2023]版:
Q3 CLINICAL NEUROLOGY Q3 RESPIRATORY SYSTEM

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第一作者机构: [1]Capital Med Univ, Xuanwu Hosp, Dept Neurol & Innovat Ctr Neurol Disorders, Natl Ctr Neurol Disorders, Beijing, Peoples R China
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通讯机构: [1]Capital Med Univ, Xuanwu Hosp, Dept Neurol & Innovat Ctr Neurol Disorders, Natl Ctr Neurol Disorders, Beijing, Peoples R China [2]Zhengzhou Univ Peoples Hosp, Henan Prov Peoples Hosp, Dept Neurol, 7 Weiwu St, Zhengzhou 450000, Peoples R China
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