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Unraveling brain aging through the lens of oral microbiota

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ 卓越：梯队期刊

作者：
Hu Qinchao[1,2] * ; Wang Si[3,4] ; Zhang Weiqi[5,6,7,8] ; Qu Jing[6,7,8,9,10] ; Liu Guang-Hui[1,3,4,6,7,8,10] ;
机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. [2]Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong Province, China. [3]Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China. [4]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, China. [5]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China. [6]University of Chinese Academy of Sciences, Beijing, China. [7]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. [8]Aging Biomarker Consortium, Beijing, China. [9]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. [10]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.
出处：
DOI： 10.4103/NRR.NRR-D-23-01761
ISSN：

摘要：
The oral cavity is a complex physiological community encompassing a wide range of microorganisms. Dysbiosis of oral microbiota can lead to various oral infectious diseases, such as periodontitis and tooth decay, and even affect systemic health, including brain aging and neurodegenerative diseases. Recent studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration, indicating potential avenues for intervention strategies. In this review, we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases, and dissect potential mechanisms by which oral microbes contribute to brain aging and neurodegeneration. We also highlight advances in therapeutic development grounded in the realm of oral microbes, with the goal of advancing brain health and promoting healthy aging.Copyright © 2025 Copyright: © 2025 Neural Regeneration Research.

基金：
This work was supported by the National Natural Science Foundation of China, No. 81921006 (to GHL).
语种：
外文
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中科院(CAS)分区：
出版当年[2025]版：
大类 | 2 区 医学
小类 | 2 区 细胞生物学 2 区 神经科学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 细胞生物学 2 区 神经科学
JCR分区：
出版当年[2023]版：
Q1 NEUROSCIENCES Q2 CELL BIOLOGY
最新[2023]版：
Q1 NEUROSCIENCES Q2 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. [2]Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
通讯作者：
通讯机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. [3]Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China. [4]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, China. [5]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China. [6]University of Chinese Academy of Sciences, Beijing, China. [7]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. [8]Aging Biomarker Consortium, Beijing, China. [9]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. [10]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.
推荐引用方式(GB/T 7714)：
Hu Qinchao,Wang Si,Zhang Weiqi,et al.Unraveling brain aging through the lens of oral microbiota[J].Neural Regeneration Research.2025,20(7):1930-1943.doi:10.4103/NRR.NRR-D-23-01761.
APA：
Hu Qinchao,Wang Si,Zhang Weiqi,Qu Jing&Liu Guang-Hui.(2025).Unraveling brain aging through the lens of oral microbiota.Neural Regeneration Research,20,(7)
MLA：
Hu Qinchao,et al."Unraveling brain aging through the lens of oral microbiota".Neural Regeneration Research 20..7(2025):1930-1943

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