机构：[1]Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.[2]China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.科技平台中美神经科学研究所首都医科大学宣武医院[3]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.神经科系统神经内科首都医科大学宣武医院[4]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.神经科系统神经外科首都医科大学宣武医院
Circadian rhythm is a master process observed in nearly every type of cell throughout the body, and it macroscopically regulates daily physiology. Recent clinical trials have revealed the effects of circadian variation on the incidence, pathophysiological processes, and prognosis of acute ischemic stroke. Furthermore, core clock genes, the cell-autonomous pacemakers of the circadian rhythm, affect the neurovascular unit-composing cells in a nonparallel manner after the same pathophysiological processes of ischemia/reperfusion. In this review, we discuss the influence of circadian rhythms and clock genes on each type of neurovascular unit cell in the pathophysiological processes of acute ischemic stroke.
基金：
This study was supported by the National Natural Science Foundation of China
grants 82027802, 82071466, 82371470, 82071468, and 82201618; “Sail
Plan” Key Medical Specialty grant ZYLX202139; “Mission” talent project of
Beijing Municipal Administration of Hospitals grant SML20150802; Beijing Municipal
Science and Technology Project grant Z181100001918026; and Project
for Innovation and Development of Beijing Municipal Geriatric Medical Research
Center 11000023T000002036320.
第一作者机构：[1]Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.[2]China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.[2]China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.[3]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.[4]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
推荐引用方式(GB/T 7714)：
Xu Shuaili,Jia Milan,Guo Jiaqi,et al.Ticking Brain: Circadian Rhythm as a New Target for Cerebroprotection[J].Stroke.2024,55(9):2385-2396.doi:10.1161/STROKEAHA.124.046684.
APA：
Xu Shuaili,Jia Milan,Guo Jiaqi,He Jiachen,Chen Xi...&Ji Xunming.(2024).Ticking Brain: Circadian Rhythm as a New Target for Cerebroprotection.Stroke,55,(9)
MLA：
Xu Shuaili,et al."Ticking Brain: Circadian Rhythm as a New Target for Cerebroprotection".Stroke 55..9(2024):2385-2396
医学