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The potential roles of PKM2 in cerebrovascular diseases

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机构: [1]Department of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, China [2]Department of Stroke Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250013, China [3]Department of Stroke Center, Shandong Second Medical University, Weifang, Shandong 261000, China [4]Department of Neurosurgery, XuanWu Hospital Capital Medical University Jinan Branch, Jinan, Shandong 250100, China
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关键词: Cerebrovascular diseases PKM2 ROS Mitochondria Post-translational modification

摘要:
Pyruvate kinase M2 (PKM2), a key enzyme involved in glycolysis,plays an important role in regulating cell metabolism and growth under different physiological conditions. PKM2 has been intensively investigated in multiple cancer diseases. Recent years, many studies have found its pivotal role in cerebrovascular diseases (CeVDs), the disturbances in intracranial blood circulation. CeVDs has been confirmed to be closely associated with oxidative stress (OS), mitochondrial dynamics, systemic inflammation, and local neuroinflammation in the brain. It has further been revealed that PKM2 exerts various biological functions in the regulation of energy supply, OS, inflammatory responses, and mitochondrial dysfunction. The roles of PKM2 are closely related to its different isoforms, expression levels in subcellular localization, and post-translational modifications. Therefore, summarizing the roles of PKM2 in CeVDs will help further understanding the molecular mechanisms of CeVDs. In this review, we illustrate the characteristics of PKM2, the regulated PKM2 expression, and the biological roles of PKM2 in CeVDs.Copyright © 2024 Elsevier B.V. All rights reserved.

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出版当年[2023]版:
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
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出版当年[2022]版:
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY
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Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY

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第一作者机构: [1]Department of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, China
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通讯机构: [2]Department of Stroke Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250013, China [4]Department of Neurosurgery, XuanWu Hospital Capital Medical University Jinan Branch, Jinan, Shandong 250100, China
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