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Therapeutic potential of microglia-derived extracellular vesicles in ischemic stroke

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收录情况： ◇ SCIE

作者：
Yan Bo[1,2] * ; Liao Pan[2,3] * ; Liu Yaru[1,2] * ; Han Zhaoli[1,2] ; Wang Conglin[1,2] ; Chen Fanglian[4] ; Lei Ping[1,2,3] ;
机构： [1]Department of Geriatrics, Tianjin Medical University General Hospital, Anshan Road No. 154, Tianjin 300052, China [2]Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Ministry of Education, Tianjin 300052, China [3]School of Medicine, Nankai University, Tianjin 300192, China [4]Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China
出处：
DOI： 10.1016/j.intimp.2024.112712
ISSN：

关键词： Microglia Extracellular vesicles Ischemic stroke

摘要：
Ischemic stroke (IS) is a debilitating neurological disorder with limited treatment options. Extracellular vesicles (EVs) have emerged as crucial lipid bilayer particles derived from various cell types that facilitate intercellular communication and enable the exchange of proteins, lipids, and genetic material. Microglia are resident brain cells that play a crucial role in brain development, maintenance of neuronal networks, and injury repair. They secrete numerous extracellular vesicles in different states. Recent evidence indicates that microglia-derived extracellular vesicles (M-EVs) actively participate in mediating various biological processes, such as neuroprotection and neurorepair, in stroke, making them an excellent therapeutic approach for treating this condition. This review comprehensively summarizes the latest research on M-EVs in stroke and explores their potential as novel therapeutic targets for this disorder. Additionally, it provides an overview of the effects and functions of M-EVs on stroke recovery to facilitate the development of clinically relevant therapies for IS.Copyright © 2024 Elsevier B.V. All rights reserved.

基金：
This research was funded by Scientific Research Program of Tianjin Education Commission (Grant No. 2022KJ246).
语种：
外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 药学 3 区 免疫学
JCR分区：
出版当年[2022]版：
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Geriatrics, Tianjin Medical University General Hospital, Anshan Road No. 154, Tianjin 300052, China [2]Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Ministry of Education, Tianjin 300052, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Geriatrics, Tianjin Medical University General Hospital, Anshan Road No. 154, Tianjin 300052, China [2]Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Ministry of Education, Tianjin 300052, China [3]School of Medicine, Nankai University, Tianjin 300192, China
推荐引用方式(GB/T 7714)：
Yan Bo,Liao Pan,Liu Yaru,et al.Therapeutic potential of microglia-derived extracellular vesicles in ischemic stroke[J].International Immunopharmacology.2024,139:112712.doi:10.1016/j.intimp.2024.112712.
APA：
Yan Bo,Liao Pan,Liu Yaru,Han Zhaoli,Wang Conglin...&Lei Ping.(2024).Therapeutic potential of microglia-derived extracellular vesicles in ischemic stroke.International Immunopharmacology,139,
MLA：
Yan Bo,et al."Therapeutic potential of microglia-derived extracellular vesicles in ischemic stroke".International Immunopharmacology 139.(2024):112712

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