机构：[1]Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China[2]Department of Neurology and Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院神经科系统神经内科神经外科[3]School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing 100191, China[4]China-America Institute of Neuroscience and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院内科系统老年医学科科技平台中美神经科学研究所[5]Department of Biomedical Engineering, Columbia University, New York, NY 10032, USA[6]Department of Biomedical Engineering, Graeme Clark Institute, University of Melbourne, Parkville, VIC 3010, Australia[7]School of Materials Science and Engineering, Peking University, Beijing 100083, China
Achieving long-lasting hypothermia neuroprotection against reperfusion injury in patients with acute ischemic stroke (AIS) by using intra-arterial selective cooling infusion with autologous blood (IASCAI) is promising. However, due to the lack of a specialized medical circulatory perfusion system matching cerebral blood flow characteristics, we conduct a translational study of an extracorporeal circulation system for continuous and controllable brain cooling using an optimized blood heat exchanger (BHE). In contrast to commercial BHEs, optimized BHEs are prone to reducing thrombogenic risk potential under a low infusion rate (10-50 mL/min) in IA-SCAI. The designed BHE provided effective cerebral cooling ('2 degrees C) ' 2 degrees C) for 22 min during a 30-min cooling period in a swine model. These results suggest that the selective brain cooling induced by cold autologous blood perfusion was safe, which could promote the clinical application of an autologous extracorporeal circulation system for AIS therapy.
基金：
Beijing Natural Science Foundation [7244510]; National Natural Science Foundation of China [82027802, 82102220, 61975017, 82071468]; Beijing Municipal Science and Technology Commission [Z221100007422023]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support from the Yangfan Project [YGLX202325]; Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences [2023-JKCS-09]; Beijing Association for Science and Technology Youth Talent Support Program [BYESS2022081]; Science and Technology Innovation Service Capacity Building Project of the Beijing Municipal Education Commission [11000023T000002157177]
第一作者机构：[1]Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China[2]Department of Neurology and Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China[3]School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing 100191, China[4]China-America Institute of Neuroscience and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Jiang Miaowen,Zhang Yang,Gao Yuan,et al.A computationally guided study of a blood heat exchanger and the construction of an extracorporeal circulation system for selective brain cooling[J].CELL REPORTS PHYSICAL SCIENCE.2024,5(6):doi:10.1016/j.xcrp.2024.102029.
APA：
Jiang, Miaowen,Zhang, Yang,Gao, Yuan,Xu, Shuaili,Qi, Zhengfei...&Li, Ming.(2024).A computationally guided study of a blood heat exchanger and the construction of an extracorporeal circulation system for selective brain cooling.CELL REPORTS PHYSICAL SCIENCE,5,(6)
MLA：
Jiang, Miaowen,et al."A computationally guided study of a blood heat exchanger and the construction of an extracorporeal circulation system for selective brain cooling".CELL REPORTS PHYSICAL SCIENCE 5..6(2024)
