机构：[1]The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Wenzhou Medical University, Wenzhou 325035, China[2]The National Clinical Research Center for Geriatric Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院[3]Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou 325000, China
Peri-operative neurocognitive disorders (PNDs) include postoperative delirium (POD) and postoperative cognitive dysfunction (POCD). Children and the elderly are the two populations most vulnerable to the development of POD and POCD, which results in both high morbidity and mortality. There are many factors, including neuroinflammation and oxidative stress, that are associated with POD and POCD. General anesthesia is a major risk factor of PNDs. However, the molecular mechanisms of PNDs are poorly understood. Dexmedetomidine (DEX) is a useful sedative agent with analgesic properties, which significantly improves POCD in elderly patients. In this review, the current understanding of anesthesia in PNDs and the protective effects of DEX are summarized, and the underlying mechanisms are further discussed.
基金：
National Natural Science Foundation of China [82150710557, 82293642]
第一作者机构：[1]The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Wenzhou Medical University, Wenzhou 325035, China
共同第一作者：
通讯作者：
通讯机构：[1]The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Wenzhou Medical University, Wenzhou 325035, China[2]The National Clinical Research Center for Geriatric Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053, China[3]Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou 325000, China
推荐引用方式(GB/T 7714)：
Li Ran,Zhang Yun,Zhu Qinxin,et al.The role of anesthesia in peri-operative neurocognitive disorders: Molecular mechanisms and preventive strategies[J].FUNDAMENTAL RESEARCH.2024,4(4):797-805.doi:10.1016/j.fmre.2023.02.007.
APA：
Li, Ran,Zhang, Yun,Zhu, Qinxin,Wu, Yili&Song, Weihong.(2024).The role of anesthesia in peri-operative neurocognitive disorders: Molecular mechanisms and preventive strategies.FUNDAMENTAL RESEARCH,4,(4)
MLA：
Li, Ran,et al."The role of anesthesia in peri-operative neurocognitive disorders: Molecular mechanisms and preventive strategies".FUNDAMENTAL RESEARCH 4..4(2024):797-805
