INTRODUCTION: CD33 rs3865444 and hypertension (HTN) are related to cognitive impairment, individually. However, little is known about their combined effects on cognitive function in older adults. METHODS: This population-based study included 4368 dementia-free participants (age >= 65 years) in the Multimodal Interventions to Delay Dementia and Disability in Rural China (MIND-China), with data available in 1044 persons for gray matter volume and 85 persons for cerebral blood flow (CBF). We used general linear regression and mediation models to examine the associations of rs3865444 and HTN with cognition, brain atrophy, and CBF. RESULTS: Among rs3865444 CC carriers, HTN and late-life HTN were significantly associated with impaired cognition. Midlife and late-life HTN were correlated with brain atrophy. CD33 rs3865444 CC moderated the mediation effect of gray matter volume on the association between HTN and global cognition. HTN was correlated with low CBF in rs3865444 CC carriers. DISCUSSION: There are synergistic associations of CD33 rs3865444 and HTN with brain and cognitive aging in dementia-free older adults.
基金：
National Key R&D Program of China Ministry of Sciences and Technology [2022YFC3501404, 2017YFC1310100]; Brain Science and Brain-Like Intelligence Technology Research Projects of China [2021ZD0201801, 2021ZD0201808]; National Natural Science Foundation of China [81861138008, 81772448, 82011530139, 82171175, 82200980]; Academic Promotion Program of Shandong First Medical University [2019QL020]; Integrated Traditional Chinese and Western Medicine Program in Shandong Province [YXH2019ZXY008]; Natural Science Foundation of Shandong Province [ZR2021MH392, ZR2021QH240, ZR2023QH019]; Postdoctoral Innovation Project of Shandong Province [SDCX-ZG-202203048]; Shandong Provincial Key Research and Development Program [2021LCZX03]; Taishan Scholar Program of Shandong Province, China; Shandong Provincial Hospital Research Incubation Fund [2022FY112]; Swedish Research Council [2017-05819, 2020-01574]; Swedish Research Council for Health, Working Life and Welfare [2023-01125]; Swedish Foundation for International Cooperation in Research and Higher Education [CH2019-8320]
第一作者机构：[1]Shandong First Med Univ, Dept Neurol, Key Lab Endocrine Glucose & Lipids Metab & Brain A, Minist Educ,Shandong Prov Hosp, 324Jingwuweiqi Rd, Jinan 250021, Shandong, Peoples R China[2]Shandong Univ, Shandong Prov Hosp, Dept Neurol, Key Lab Endocrine Glucose & Lipids Metab & Brain A, Jinan, Shandong, Peoples R China[3]Shandong Prov Clin Res Ctr Neurol Dis, Jinan, Shandong, Peoples R China
通讯作者：
通讯机构：[1]Shandong First Med Univ, Dept Neurol, Key Lab Endocrine Glucose & Lipids Metab & Brain A, Minist Educ,Shandong Prov Hosp, 324Jingwuweiqi Rd, Jinan 250021, Shandong, Peoples R China[2]Shandong Univ, Shandong Prov Hosp, Dept Neurol, Key Lab Endocrine Glucose & Lipids Metab & Brain A, Jinan, Shandong, Peoples R China[3]Shandong Prov Clin Res Ctr Neurol Dis, Jinan, Shandong, Peoples R China[6]Shandong First Med Univ, Inst Brain Sci & Brain Inspired Res, Jinan, Shandong, Peoples R China[7]Stockholm Univ, Karolinska Inst, Aging Res Ctr, Stockholm, Sweden[8]Stockholm Univ, Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden
推荐引用方式(GB/T 7714)：
Zhu Min,Tian Xunyao,Han Xiaodong,et al.Synergistic associations of CD33 variants and hypertension with brain and cognitive aging among dementia-free older adults: A population-based study[J].ALZHEIMERS & DEMENTIA.2024,20(10):7193-7204.doi:10.1002/alz.14209.
APA：
Zhu, Min,Tian, Xunyao,Han, Xiaodong,Ma, Yixun,Fa, Wenxin...&Du, Yifeng.(2024).Synergistic associations of CD33 variants and hypertension with brain and cognitive aging among dementia-free older adults: A population-based study.ALZHEIMERS & DEMENTIA,20,(10)
MLA：
Zhu, Min,et al."Synergistic associations of CD33 variants and hypertension with brain and cognitive aging among dementia-free older adults: A population-based study".ALZHEIMERS & DEMENTIA 20..10(2024):7193-7204
医学