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Clinicopathologic features and surgery-related outcomes of duodenal adenocarcinoma: A multicenter retrospective study

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Xiao Qifeng[1] * ; Wu Xin[2] ; Yuan Chunhui[3] ; Gu Zongting[4] ; Tang Xiaolong[5] ; Meng Fanbin[6] ; Wang Dong[7] ; Lang Ren[8] ; Zhai Gang[9] ; Tian Xiaodong[10] ; Zhang Yu[11] ; Zhao Enhong[12] ; Zhao Xiaodong[13] ; Cao Feng[14] ; Xu Jingyong[15] ; Xing Ying[16] ; Wang Chengfeng[1] ; Zhang Jianwei[1] ;
机构： [1]Pancreatic and Gastric Surgery Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China [2]Department of General Surgery, First Medical Center of Chinese PLA General Hospital, Beijing, China [3]Department of General Surgery, Peking University Third Hospital, Beijing, China [4]General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China [5]Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China [6]Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China [7]Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China [8]Department of Hepatobiliary and Pancreaticosplenic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China [9]Hepatobiliary and Pancreatogastric Surgery, Shanxi Provincial Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Taiyuan, Shanxi, China [10]Department of General Surgery, Peking University First Hospital, Beijing, China [11]Department of Hepatobiliary Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China [12]Gastrointestinal Surgery Department, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, China [13]Department of Oncological Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China [14]General Surgery Department, Xuanwu Hospital, Capital Medical University, Beijing, China [15]Department of General Surgery, Beijing Hospital, Beijing, China [16]General Surgery Department, Capital Medical University Beijing Affiliated Tiantan Hospital, Beijing, China
出处：
DOI： 10.1016/j.surg.2024.08.007
ISSN：

摘要：
The incidence of duodenal adenocarcinoma is increasing, with limited studies on this disease published. This multicenter retrospective study aimed to analyze the clinicopathologic features of duodenal adenocarcinoma and identify prognostic factors for postoperative survival.Demographic characteristics, clinicopathologic features, treatment outcomes, and survival of patients with duodenal adenocarcinoma undergoing surgical treatment at 16 Chinese medical centers from 2012 to 2023 were retrospectively analyzed.Among the 2,189 patients with duodenal adenocarcinoma included, 50.07% had extra-ampullary duodenal adenocarcinoma and 49.93% had peri-ampullary duodenal adenocarcinoma. The 1-, 3-, and 5-year overall survival rates for patients who underwent radical surgery were 91.78%, 69.30%, and 55.86%, respectively. The median overall survival was 73 months (range, 64-84), and the median progression-free survival was 64 months (range, 52-76). No differences in survival were observed between the laparotomy and minimally invasive surgery groups (log-rank P = .562); furthermore, no significant between-group differences in operation time, lymph node dissection, postoperative complications, or in-hospital mortality were observed (P > .05). The minimally invasive surgery group experienced less intraoperative blood loss (250 mL vs 100 mL, P < .001), fewer intraoperative blood transfusions (24.97% vs 18.84%, P = .002), and shorter hospital stays (28 days vs 23 days, P < .001). Multivariate Cox regression analysis revealed that advanced age, advanced stage, longer operation time, intraoperative blood transfusion, and postoperative hemorrhage were independent risk factors for poor prognosis.Radical surgery was associated with favorable overall survival among patients with duodenal adenocarcinoma, and no difference in survival was observed between patients with extra-ampullary duodenal adenocarcinoma and peri-ampullary duodenal adenocarcinoma. Minimally invasive surgery is a reliable alternative for duodenal adenocarcinoma treatment.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

基金：
This work was supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (grant number 2022-I2M-1-010).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 外科
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 外科
JCR分区：
出版当年[2022]版：
Q1 SURGERY
最新[2023]版：
Q1 SURGERY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Pancreatic and Gastric Surgery Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
通讯作者：
推荐引用方式(GB/T 7714)：
Xiao Qifeng,Wu Xin,Yuan Chunhui,et al.Clinicopathologic features and surgery-related outcomes of duodenal adenocarcinoma: A multicenter retrospective study[J].Surgery.2024,176(6):1745-1753.doi:10.1016/j.surg.2024.08.007.
APA：
Xiao Qifeng,Wu Xin,Yuan Chunhui,Gu Zongting,Tang Xiaolong...&Zhang Jianwei.(2024).Clinicopathologic features and surgery-related outcomes of duodenal adenocarcinoma: A multicenter retrospective study.Surgery,176,(6)
MLA：
Xiao Qifeng,et al."Clinicopathologic features and surgery-related outcomes of duodenal adenocarcinoma: A multicenter retrospective study".Surgery 176..6(2024):1745-1753

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