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Metformin decelerates aging clock in male monkeys

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Yuanhan Yang[1,10] * ; Xiaoyong Lu[2,3,10] * ; Ning Liu[7,8] * ; Shuai Ma[1,4,5,10] * ; Hui Zhang[1,10,13] * ; Zhiyi Zhang[7] * ; Kuan Yang[2,3,10] ; Mengmeng Jiang[1,4,5] ; Zikai Zheng[2,3,10] ; Yicheng Qiao[7,8] ; Qinchao Hu[1,11] ; Ying Huang[12] ; Yiyuan Zhang[1,4,5] ; Muzhao Xiong[2,3,10] ; Lixiao Liu[2,3,10] ; Xiaoyu Jiang[1,10] ; Pradeep Reddy[15] ; Xueda Dong[7,9] ; Fanshu Xu[7,8] ; Qiaoran Wang[2,3,10] ; Qian Zhao[6] ; Jinghui Lei[6] ; Shuhui Sun[13] ; Ying Jing[6] ; Jingyi Li[1,4,5,22] ; Yusheng Cai[1,4,5] ; Yanling Fan[2,3] ; Kaowen Yan[1,4,5] ; Yaobin Jing[1,4,5,14] ; Amin Haghani[15] ; Mengen Xing[19] ; Xuan Zhang[20] ; Guodong Zhu[21] ; Weihong Song[19] ; Steve Horvath[15] ; Concepcion Rodriguez Esteban[15] ; Moshi Song[1,5,10] ; Si Wang[6,22] ; Guoguang Zhao[16,17,18] ; Wei Li[1,4,5,10] ; Juan Carlos Izpisua Belmonte[15] ; Jing Qu[1,4,5,10,13,22] ; Weiqi Zhang[2,3,4,5,10,22] ; Guang-Hui Liu[1,4,5,6,10,22] ;
机构： [1]Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Membrane Biology, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]China National Center for Bioinformation, Beijing, China [3]Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China [4]Institute for Stem Cell and Regeneration, CAS, Beijing 100101, China [5]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [6]National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital Capital Medical University, Beijing 100053, China [7]State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [8]College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China [9]Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100049, China [10]University of Chinese Academy of Sciences, Beijing 100049, China [11]Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-Sen University, Guangzhou 510060, China [12]Chongqing Fifth People’s Hospital, Chongqing 400060, China [13]Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China [14]International Center for Aging and Cancer, Hainan Medical University, Haikou 571199, China [15]Altos Labs San Diego Institute of Science, San Diego, CA, USA [16]Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing 100053, China [17]National Medical Center for Neurological Diseases, Beijing 100053, China [18]Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China [19]Oujiang Laboratory, Center for Geriatric Medicine and Institute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Zhejiang Provincial Clinical Research for Mental Disorders, The First-Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China [20]Department of Rheumatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Clinical Immunology Center, Chinese Academy of Medical Sciences, Beijing 100730, China [21]Institute of Gerontology, Guangzhou Geriatric Hospital, Guangzhou Medical University, Guangzhou, China [22]Aging Biomarker Consortium (ABC), Beijing 100101, China
出处：
DOI： 10.1016/j.cell.2024.08.021
ISSN：

摘要：
In a rigorous 40-month study, we evaluated the geroprotective effects of metformin on adult male cynomolgus monkeys, addressing a gap in primate aging research. The study encompassed a comprehensive suite of physiological, imaging, histological, and molecular evaluations, substantiating metformin's influence on delaying age-related phenotypes at the organismal level. Specifically, we leveraged pan-tissue transcriptomics, DNA methylomics, plasma proteomics, and metabolomics to develop innovative monkey aging clocks and applied these to gauge metformin's effects on aging. The results highlighted a significant slowing of aging indicators, notably a roughly 6-year regression in brain aging. Metformin exerts a substantial neuroprotective effect, preserving brain structure and enhancing cognitive ability. The geroprotective effects on primate neurons were partially mediated by the activation of Nrf2, a transcription factor with anti-oxidative capabilities. Our research pioneers the systemic reduction of multi-dimensional biological age in primates through metformin, paving the way for advancing pharmaceutical strategies against human aging.Copyright © 2024 Elsevier Inc. All rights reserved.

基金：
This work was supported by the National Key Research and Development Program of China (2022YFA1103700, 2022YFA1103800)), the National Natural Science Foundation of China (82125011, 92168201, 81921006, 92149301, 82122024, 82322025, and 82361148131), the Program of the Beijing Natural Science Foundation (JQ24044), the National Key Research and Development Program of China (2020YFA0804000, the STI2030-Major Projects- 2021ZD0202400, 2023YFC3605400, 2020YFA0112200, 2021YFF1201000, 2023YFC3504301, 2020YFA0113400, 2021YFA1101000, 2021ZD0200200, and 2022YFC3602000), the National Natural Science Foundation of China (82330044, 32341001, 92049304, 92049116, 32121001, 82192863, 82271600, 82071588, 82361148130, 8231101626, 82201727, 82230060, 81788101, 32141004, 82203021, and 82171799), CAS Project for Young Scientists in Basic Research (YSBR-076, YSBR-012, and YSBR-036), the Program of the Beijing Natural Science Foundation (Z230011, Z240018, 5244046, and 5242024), the Informatization Plan of Chinese Academy of Sciences (CAS-WX2022SDC-XK14), New Cornerstone Science Foundation through the XPLORER PRIZE (2021-1045), Youth Innovation Promotion Association of CAS (E1CAZW0401, 2020085, 2022083, and 2023092), Young Elite Scientists Sponsorship Program by CAST (2021QNRC001), Initiative Scientific Research Program, Institute of Zoology, CAS (2023IOZ0102), Postdoctoral Fellowship Program of CPSF (GZC20232647), Beijing Hospitals Authority Youth Programme (QML20230806), Excellent Young Talents Program of Capital Medical University (12300927), the Project for Technology Development of Beijing-Affiliated Medical Research Institutes (11000023T000002036310), Excellent Young Talents Training Program for the Construction of Beijing Municipal University Teacher Team (BPHR202203105), Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes (JYY2023-13), and CAS Youth Interdisciplinary Team. We thank the support from the Proteomic Navigator of the Human Body (p-HuB) Project.
语种：
外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
JCR分区：
出版当年[2022]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Membrane Biology, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [10]University of Chinese Academy of Sciences, Beijing 100049, China
共同第一作者：
通讯作者：
通讯机构： [1]Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Membrane Biology, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]China National Center for Bioinformation, Beijing, China [3]Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China [4]Institute for Stem Cell and Regeneration, CAS, Beijing 100101, China [5]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [6]National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital Capital Medical University, Beijing 100053, China [10]University of Chinese Academy of Sciences, Beijing 100049, China [13]Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China [22]Aging Biomarker Consortium (ABC), Beijing 100101, China
推荐引用方式(GB/T 7714)：
Yuanhan Yang,Xiaoyong Lu,Ning Liu,et al.Metformin decelerates aging clock in male monkeys[J].Cell.2024,187(22):doi:10.1016/j.cell.2024.08.021.
APA：
Yuanhan Yang,Xiaoyong Lu,Ning Liu,Shuai Ma,Hui Zhang...&Guang-Hui Liu.(2024).Metformin decelerates aging clock in male monkeys.Cell,187,(22)
MLA：
Yuanhan Yang,et al."Metformin decelerates aging clock in male monkeys".Cell 187..22(2024)

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