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Glutathione restoration: a sword to combat skeletal muscle stem cell aging

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收录情况: ◇ 卓越:高起点新刊 ◇ ESCI

机构: [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [3]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [4]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China [5]University of Chinese Academy of Sciences, Beijing 100049, China [6]Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China [7]Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China [8]Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
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摘要:
In a recent study published in Cell Metabolism, Thomas A. Rando and colleagues reported a critical role of dysregulated glutathione (GSH) metabolism in driving the aging process of skeletal muscle stem cells (MuSCs), uncovering a novel mechanism underlying the divergent responses of quiescent stem cells to environmental stressors with age, thus providing a potentially accessible target to alleviate age-associated skeletal muscle degeneration.

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第一作者机构: [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [3]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China
通讯作者:
通讯机构: [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [3]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [4]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China [5]University of Chinese Academy of Sciences, Beijing 100049, China [6]Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China [7]Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China [8]Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
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