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A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium

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机构: [1]Third Mil Med Univ, Daping Hosp, Dept Neurol, Chongqing 400042, Peoples R China [2]Third Mil Med Univ, Daping Hosp, Ctr Clin Neurosci, Chongqing 400042, Peoples R China [3]Shanxi Med Univ, Affiliated Hosp 1, Dept Neurol, Taiyuan 030001, Peoples R China [4]Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing 100053, Peoples R China [5]Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Neurol, Sch Med, Shanghai 200025, Peoples R China [6]Shanghai Jiao Tong Univ, Inst Neurol, Ruijin Hosp, Sch Med, Shanghai 200025, Peoples R China [7]Fujian Med Univ, Dept Neurol, Union Hosp, Fuzhou 350001, Peoples R China [8]Shanghai Jiao Tong Univ, Dept Gerontol, Sch Med, Shanghai Peoples Hosp 6, Shanghai 200233, Peoples R China [9]Tongji Univ, Sch Med,Shanghai Sunshine Rehabil Ctr, Shanghai Disabled Persons Federat Key Lab Intelli, Dept Neurol & Neurol Rehabil,Yangzhi Rehabil Hosp, Shanghai 200092, Peoples R China [10]Univ Sci & Technol China, Hefei Natl Lab Phys Sci, Affiliated Hosp USTC 1, Inst Aging & Brain Disorders,Div Life Sci & Med, Hefei 230026, Peoples R China [11]Tianjin Med Univ Gen Hosp, Inst Neuroimmunol, Dept Neurol, Tianjin 300052, Peoples R China [12]Tongji Univ, Shanghai Tongji Hosp, Dept Cardiol, Sch Med, Shanghai 200092, Peoples R China [13]Tongji Univ, Shanghai Key Lab Maternal Fetal Med,Sch Life Sci, Clin & Translat Res Ctr,Shanghai Matern & Infant, Shanghai Key Lab Signaling & Dis Res,Frontier Sci, Shanghai 200092, Peoples R China [14]Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China [15]Wenzhou Med Univ, Zhejiang Clin Res Ctr Mental Disorders, Oujiang Lab,Sch Mental Hlth, Inst Aging,Key Lab Alzheimers Dis Zhejiang Prov, Wenzhou 325035, Zhejiang, Peoples R China [16]Wenzhou Med Univ, Oujiang Lab, Kangning Hosp 2, Wenzhou 325035, Zhejiang, Peoples R China [17]Capital Med Univ, Natl Ctr Neurol Disorders, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R China [18]Capital Med Univ, Xuanwu Hosp, Innovat Ctr Neurol Disorders, Natl Ctr Neurol Disorders, Beijing 100053, Peoples R China [19]China Med Univ, Dept Gerontol, Shengjing Hosp, Shenyang 110000, Peoples R China [20]Tongji Univ, Shanghai Frontiers Sci Ctr Nanocatalyt Med, Inst Biomed Engn & Nano Sci, Dept Radiol,Tongji Hosp,Sch Med, Shanghai 200092, Peoples R China [21]Tongji Univ, Shanghai Peoples Hosp 4, Translat Res Inst Brain & Brain Like Intelligence, Shanghai Key Lab Anesthesiol & Brain Funct Modula, Shanghai 200434, Peoples R China [22]Chinese Acad Sci, Shenzhen Inst Adv Technol, Fac Life & Hlth Sci, Shenzhen 518055, Peoples R China [23]Wuhan Univ, Dept Neurol, Zhongnan Hosp, Wuhan 430071, Peoples R China [24]Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genom & Precis Med, Beijing 100101, Peoples R China [25]China Natl Ctr Bioinformat, Beijing 100101, Peoples R China [26]Tongji Univ, Shanghai East Hosp, Sch Med, Translat Med Ctr Stem Cell Therapy, Shanghai 200120, Peoples R China [27]Xiamen Univ, Inst Neurosci, Sch Med, Fujian Prov Key Lab Neurodegenerat Dis & Aging Re, Xiamen 361102, Peoples R China [28]Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China [29]Cent South Univ, Xiangya Hosp, Dept Crit Care Med, Hunan Key Lab Mol Precis Med, Changsha 410008, Peoples R China [30]Tongji Univ, Ctr Translat Neurodegenerat & Regenerat Therapy, Tongji Hosp, Sch Med, Shanghai 200072, Peoples R China [31]Univ Chinese Acad Sci, Beijing 100049, Peoples R China [32]Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China [33]Tongji Univ, Tongji Hosp, Stem Cell Translat Res Ctr, Sch Med, Shanghai 200065, Peoples R China [34]Key Lab Ageing & Brain Dis, Chongqing 400042, Peoples R China [35]Tongji Univ, Sch Life Sci & Technol, Collaborat Innovat Ctr Brain Sci, Shanghai 200092, Peoples R China
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摘要:
China and the world are facing severe population aging and an increasing burden of age-related diseases. Aging of the brain causes major age-related brain diseases, such as neurodegenerative diseases and stroke. Identifying biomarkers for the effective assessment of brain aging and establishing a brain aging assessment system could facilitate the development of brain aging intervention strategies and the effective prevention and treatment of aging-related brain diseases. Thus, experts from the Aging Biomarker Consortium (ABC) have combined the latest research results and practical experience to recommend brain aging biomarkers and form an expert consensus, aiming to provide a basis for assessing the degree of brain aging and conducting brain-aging-related research with the ultimate goal of improving the brain health of elderly individuals in both China and the world.

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第一作者机构: [1]Third Mil Med Univ, Daping Hosp, Dept Neurol, Chongqing 400042, Peoples R China [2]Third Mil Med Univ, Daping Hosp, Ctr Clin Neurosci, Chongqing 400042, Peoples R China [3]Shanxi Med Univ, Affiliated Hosp 1, Dept Neurol, Taiyuan 030001, Peoples R China
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通讯作者:
通讯机构: [1]Third Mil Med Univ, Daping Hosp, Dept Neurol, Chongqing 400042, Peoples R China [2]Third Mil Med Univ, Daping Hosp, Ctr Clin Neurosci, Chongqing 400042, Peoples R China [5]Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Neurol, Sch Med, Shanghai 200025, Peoples R China [6]Shanghai Jiao Tong Univ, Inst Neurol, Ruijin Hosp, Sch Med, Shanghai 200025, Peoples R China [10]Univ Sci & Technol China, Hefei Natl Lab Phys Sci, Affiliated Hosp USTC 1, Inst Aging & Brain Disorders,Div Life Sci & Med, Hefei 230026, Peoples R China [11]Tianjin Med Univ Gen Hosp, Inst Neuroimmunol, Dept Neurol, Tianjin 300052, Peoples R China [14]Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China [15]Wenzhou Med Univ, Zhejiang Clin Res Ctr Mental Disorders, Oujiang Lab,Sch Mental Hlth, Inst Aging,Key Lab Alzheimers Dis Zhejiang Prov, Wenzhou 325035, Zhejiang, Peoples R China [16]Wenzhou Med Univ, Oujiang Lab, Kangning Hosp 2, Wenzhou 325035, Zhejiang, Peoples R China [17]Capital Med Univ, Natl Ctr Neurol Disorders, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R China [18]Capital Med Univ, Xuanwu Hosp, Innovat Ctr Neurol Disorders, Natl Ctr Neurol Disorders, Beijing 100053, Peoples R China [24]Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genom & Precis Med, Beijing 100101, Peoples R China [25]China Natl Ctr Bioinformat, Beijing 100101, Peoples R China [31]Univ Chinese Acad Sci, Beijing 100049, Peoples R China [32]Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China [34]Key Lab Ageing & Brain Dis, Chongqing 400042, Peoples R China
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