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A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement

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机构: [1]Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Med Ctr 2, Dept Cardiol, Beijing 100853, Peoples R China [2]Chinese Acad Med Sci & Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China [3]Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Chil, Dept Paediat, West China Second Univ Hosp,State Key Lab Biother, Chengdu 610041, Peoples R China [4]Chinese Acad Sci, State Key Lab Membrane Biol, Inst Zool, Beijing 100101, Peoples R China [5]Univ Chinese Acad Sci, Beijing 100049, Peoples R China [6]Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China [7]Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China [8]Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Dept Cardiol, Shanghai 200433, Peoples R China [9]Natl Hlth Commiss, Key Lab Viral Heart Dis, Shanghai 200433, Peoples R China [10]Chinese Acad Med Sci, Key Lab Viral Heart Dis, Shanghai 200433, Peoples R China [11]Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China [12]Chinese Acad Med Sci & Peking Union Med Coll, Inst Basic Med Sci, Dept Biochem & Mol Biol, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China [13]Peking Univ Third Hosp, Dept Cardiol, Beijing 100191, Peoples R China [14]Peking Univ Third Hosp, Inst Vasc Med, Beijing 100191, Peoples R China [15]Peking Univ, NHC Key Lab Cardiovasc Mol Biol & Regulatory Pepti, State Key Lab Vasc Homeostasis & Remodeling, Beijing 100191, Peoples R China [16]Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Clin Pharmacol Ctr, Natl Ctr Cardiovasc Dis, Beijing 100037, Peoples R China [17]Shanghai Jiao Tong Univ, Dept Cardiol, State Key Lab Oncogenes & Related Genes, Shanghai 200025, Peoples R China [18]Peking Univ, Beijing Key Lab Cardiovasc Receptors Res, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, State Key Lab Vasc Homeostasis & Remodeling, Beijing 100191, Peoples R China [19]Peking Univ Third Hosp, Dept Pharm, Beijing 100191, Peoples R China [20]Shanghai Univ, Shanghai Engn Res Ctr Organ Repair, Sch Med, Shanghai 200444, Peoples R China [21]Shanghai Univ, Inst Cardiovasc Sci, Sch Life Sci, Cardiac Regenerat & Ageing Lab, Shanghai 200444, Peoples R China [22]Capital Med Univ, Beijing Friendship Hosp, Beijing Clin Res Inst, Lab Cardiovasc Sci, Beijing 100050, Peoples R China [23]Capital Inst Pediat, Beijing 100020, Peoples R China [24]Peking Union Med Coll, Grad Sch, Beijing 100730, Peoples R China [25]Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing 100871, Peoples R China [26]Peking Univ, Minist Educ, Inst Cardiovasc Sci, Key Lab Mol Cardiovasc Sci,Hlth Sci Ctr, Beijing 100191, Peoples R China [27]Peking Univ, Sch Basic Med Sci, Key Lab Mol Cardiovasc Sci, Minist Educ,Hlth Sci Ctr, Beijing 100191, Peoples R China [28]Cent South Univ, Xiangya Hosp 3, Clin Res Ctr, Changsha 410013, Peoples R China [29]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Dept Cardiol, Beijing 100029, Peoples R China [30]Third Mil Med Univ, Daping Hosp, Dept Neurol, Chongqing 400042, Peoples R China [31]Third Mil Med Univ, Daping Hosp, Ctr Clin Neurosci, Chongqing 400042, Peoples R China [32]Third Mil Med Univ, Inst Brain & Intelligence, Chongqing 400042, Peoples R China [33]Chongqing Key Lab Ageing & Brain Dis, Chongqing 400016, Peoples R China [34]Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai 200031, Peoples R China [35]Gerontol Ctr Hubei Prov, Wuhan 430000, Peoples R China [36]Huazhong Univ Sci & Technol, Tongji Hosp, Inst Gerontol, Tongji Med Coll, Wuhan 430030, Peoples R China [37]Chinese Acad Med Sci, Beijing Hosp, Beijing Inst Geriatr, Inst Geriatr Med,Key Lab Geriatr,Natl Ctr Gerontol, Beijing 100730, Peoples R China [38]Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genom & Precis Med, Beijing 100101, Peoples R China [39]China Natl Ctr Bioinformat, Beijing 100101, Peoples R China [40]Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Peoples R China [41]Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China [42]Peking Univ, Peking Univ Third Hosp, Key Lab Mol Cardiovasc Sci, NHC Key Lab Cardiovasc Mol Biol & Regulatory Pepti, Beijing 100191, Peoples R China [43]Peking Univ, Peking Univ Third Hosp, Key Lab Mol Cardiovasc Sci, Inst Vasc Med,NHC Key Lab Cardiovasc Mol Biol & Re, Beijing 100191, Peoples R China [44]Capital Med Univ, Xuanwu Hosp, Adv Innovat Ctr Human Brain Protect, Beijing 100053, Peoples R China [45]Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Disorders, Beijing 100053, Peoples R China [46]Tongji Univ, Collaborat Innovat Ctr Brain Sci, Sch Life Sci & Technol, Shanghai Key Lab Signaling & Dis Res,Lab Receptor, Shanghai 200070, Peoples R China
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摘要:
Cardiac aging constitutes a significant risk factor for cardiovascular diseases prevalent among the elderly population. Urgent attention is required to prioritize preventive and management strategies for age-related cardiovascular conditions to safeguard the well-being of elderly individuals. In response to this critical challenge, the Aging Biomarker Consortium (ABC) of China has formulated an expert consensus on cardiac aging biomarkers. This consensus draws upon the latest scientific literature and clinical expertise to provide a comprehensive assessment of biomarkers associated with cardiac aging. Furthermore, it presents a standardized methodology for characterizing biomarkers across three dimensions: functional, structural, and humoral. The functional dimension encompasses a broad spectrum of markers that reflect diastolic and systolic functions, sinus node pacing, neuroendocrine secretion, coronary microcirculation, and cardiac metabolism. The structural domain emphasizes imaging markers relevant to concentric cardiac remodeling, coronary artery calcification, and epicardial fat deposition. The humoral aspect underscores various systemic (N) and heart-specific (X) markers, including endocrine hormones, cytokines, and other plasma metabolites. The ABC's primary objective is to establish a robust foundation for assessing cardiac aging, thereby furnishing a dependable reference for clinical applications and future research endeavors. This aims to contribute significantly to the enhancement of cardiovascular health and overall well-being among elderly individuals.

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第一作者机构: [1]Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Med Ctr 2, Dept Cardiol, Beijing 100853, Peoples R China
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通讯机构: [2]Chinese Acad Med Sci & Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China [4]Chinese Acad Sci, State Key Lab Membrane Biol, Inst Zool, Beijing 100101, Peoples R China [5]Univ Chinese Acad Sci, Beijing 100049, Peoples R China [6]Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China [7]Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China [8]Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Dept Cardiol, Shanghai 200433, Peoples R China [9]Natl Hlth Commiss, Key Lab Viral Heart Dis, Shanghai 200433, Peoples R China [10]Chinese Acad Med Sci, Key Lab Viral Heart Dis, Shanghai 200433, Peoples R China [11]Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China [13]Peking Univ Third Hosp, Dept Cardiol, Beijing 100191, Peoples R China [14]Peking Univ Third Hosp, Inst Vasc Med, Beijing 100191, Peoples R China [15]Peking Univ, NHC Key Lab Cardiovasc Mol Biol & Regulatory Pepti, State Key Lab Vasc Homeostasis & Remodeling, Beijing 100191, Peoples R China [16]Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Clin Pharmacol Ctr, Natl Ctr Cardiovasc Dis, Beijing 100037, Peoples R China [18]Peking Univ, Beijing Key Lab Cardiovasc Receptors Res, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, State Key Lab Vasc Homeostasis & Remodeling, Beijing 100191, Peoples R China [19]Peking Univ Third Hosp, Dept Pharm, Beijing 100191, Peoples R China [20]Shanghai Univ, Shanghai Engn Res Ctr Organ Repair, Sch Med, Shanghai 200444, Peoples R China [21]Shanghai Univ, Inst Cardiovasc Sci, Sch Life Sci, Cardiac Regenerat & Ageing Lab, Shanghai 200444, Peoples R China [22]Capital Med Univ, Beijing Friendship Hosp, Beijing Clin Res Inst, Lab Cardiovasc Sci, Beijing 100050, Peoples R China [23]Capital Inst Pediat, Beijing 100020, Peoples R China [24]Peking Union Med Coll, Grad Sch, Beijing 100730, Peoples R China [25]Peking Univ, Inst Mol Med, Coll Future Technol, State Key Lab Membrane Biol, Beijing 100871, Peoples R China [26]Peking Univ, Minist Educ, Inst Cardiovasc Sci, Key Lab Mol Cardiovasc Sci,Hlth Sci Ctr, Beijing 100191, Peoples R China [27]Peking Univ, Sch Basic Med Sci, Key Lab Mol Cardiovasc Sci, Minist Educ,Hlth Sci Ctr, Beijing 100191, Peoples R China [30]Third Mil Med Univ, Daping Hosp, Dept Neurol, Chongqing 400042, Peoples R China [31]Third Mil Med Univ, Daping Hosp, Ctr Clin Neurosci, Chongqing 400042, Peoples R China [32]Third Mil Med Univ, Inst Brain & Intelligence, Chongqing 400042, Peoples R China [33]Chongqing Key Lab Ageing & Brain Dis, Chongqing 400016, Peoples R China [34]Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai 200031, Peoples R China [35]Gerontol Ctr Hubei Prov, Wuhan 430000, Peoples R China [36]Huazhong Univ Sci & Technol, Tongji Hosp, Inst Gerontol, Tongji Med Coll, Wuhan 430030, Peoples R China [38]Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genom & Precis Med, Beijing 100101, Peoples R China [39]China Natl Ctr Bioinformat, Beijing 100101, Peoples R China [41]Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China [42]Peking Univ, Peking Univ Third Hosp, Key Lab Mol Cardiovasc Sci, NHC Key Lab Cardiovasc Mol Biol & Regulatory Pepti, Beijing 100191, Peoples R China [43]Peking Univ, Peking Univ Third Hosp, Key Lab Mol Cardiovasc Sci, Inst Vasc Med,NHC Key Lab Cardiovasc Mol Biol & Re, Beijing 100191, Peoples R China [44]Capital Med Univ, Xuanwu Hosp, Adv Innovat Ctr Human Brain Protect, Beijing 100053, Peoples R China [45]Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Disorders, Beijing 100053, Peoples R China
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