INTRODUCTION: This study aims to investigate the relationship between blood-based pathologies and established risk factors for cognitive decline in the community-based population of Chongqing, a region with significant aging. METHODS: A total of 26,554 residents aged 50 years and older were recruited. Multinomial logistic regression models were applied to assess the risk factors of cognition levels. Propensity score matching and linear mixed effects models were used to evaluate the relationship between key risk factors and the circulating biomarkers. RESULTS: Shared and distinct risk factors for MCI and dementia were identified. Age, lower education, medical history of stroke, hypertension, and epilepsy influenced mild cognitive impairment (MCI) progression to dementia. Correlations between key risk factors and circulating neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), amyloid beta protein (A beta)40, and A beta 42/A beta 40 ratio suggest underlying mechanisms contributing to cognitive impairment. DISCUSSION: The common and distinct risk factors across cognitive decline stages emphasize the need for tailored interventions. The correlations with blood biomarkers provide insights into potential management targets.
基金：
National Natural Science Foundation of China; Canadian Institutes of Health Research [TAD-117948]; Canada Research Chair in Alzheimer's Disease; China Scholarship Council's Visiting Scholarship; [81161120498]; [82293642]; [82230043]; [82150710557]; [82201576]
第一作者机构：[1]Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Child Neurodev & Cognit Disorder, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China[2]Univ British Columbia, Dept Psychiat, Townsend Family Labs, Vancouver, BC, Canada
共同第一作者：
通讯作者：
通讯机构：[1]Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Child Neurodev & Cognit Disorder, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China[2]Univ British Columbia, Dept Psychiat, Townsend Family Labs, Vancouver, BC, Canada[9]Wenzhou Med Univ, Affiliated Hosp 1, Inst Aging, Ctr Geriatr Med,Key Lab Alzheimers Dis Zhejiang Pr, Wenzhou, Zhejiang, Peoples R China[10]Zhejiang Lab Regenerat Med Vis & Brain Hlth, Oujiang Lab, Wenzhou, Zhejiang, Peoples R China[11]Nanjing Univ, Nanjing Drum Tower Hosp, Med Sch, Dept Neurol,Affiliated Hosp, 321 Zhongshan Rd, Nanjing 210008, Peoples R China[12]Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing, Peoples R China[*1]Wenzhou Med Univ, Affiliated Hosp 1, Inst Aging, Ctr Geriatr Med, Wenzhou 325000, Zhejiang, Peoples R China[*2]Chongqing Med Univ, Chongqing Key Lab Child Neurodev & Cognit Disorder, Childrens Hosp, Chongqing 400016, Peoples R China
推荐引用方式(GB/T 7714)：
Kang Yu,Feng Zijuan,Zhang Qian,et al.Identification of circulating risk biomarkers for cognitive decline in a large community-based population in Chongqing China[J].ALZHEIMERS & DEMENTIA.2025,21(2):doi:10.1002/alz.14443.
APA：
Kang, Yu,Feng, Zijuan,Zhang, Qian,Liu, Mingjing,Li, Yanhua...&Zhang, Yun.(2025).Identification of circulating risk biomarkers for cognitive decline in a large community-based population in Chongqing China.ALZHEIMERS & DEMENTIA,21,(2)
MLA：
Kang, Yu,et al."Identification of circulating risk biomarkers for cognitive decline in a large community-based population in Chongqing China".ALZHEIMERS & DEMENTIA 21..2(2025)
医学