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Overexpression of α-synuclein in PDF neurons alters sleep-wake pattern by regulating lipid metabolism in Drosophila

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机构： [1]Department of Neurology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, China. [2]Department of Neurology and Clinical Research Center of Neurological Disease, Second Affiliated Hospital of Soochow University, Suzhou, China. [3]Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, China. [4]Cambridge-Suda Genomic Resource Center, Soochow University, Suzhou, China. [5]Department of Neurology, Xiongan Xuanwu Hospital, Xiongan, China.

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关键词： Parkinson's disease α-synuclein sleep-wake patterm Pigment Dispersing Factor neuron lipid metabolism

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Parkinson's disease (PD) is a complex neurodegenerative disorder, characterized by the aggregation of α-synuclein (α-syn). Current research increasingly indicates the prevalence of sleep-wake disorders in early-stage PD, although the underlying pathogenic mechanisms remain unclear. In this study, transgenic Drosophila models were utilized to observe excessive daytime sleepiness and impaired anticipation in flies overexpressing α-syn in pan-neurons and circadian clock neurons. Additionally, deficits in projection of Pigment Dispersing Factor (PDF) neuron terminals, which are involved in Drosophila sleep and circadian rhythm, were identified. An imbalance in lipid metabolism homeostasis was detected in the brains of α-syn overexpressing mutants. Ultimately, the inhibition of Sterol Regulatory Element-Binding Protein (SREBP) activity led to an improvement in the reduced daytime sleep duration phenotype. Our results suggest that lipid pathways play a role in sleep-wake disorders triggered by α-syn mutation and aggregation, thereby providing valuable insights into potential therapeutic avenues for disrupted sleep patterns associated with PD.© The Author(s) 2024. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

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出版当年[2023]版：

大类 | 2 区医学

小类 | 2 区临床神经病学 2 区神经科学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区临床神经病学 2 区神经科学

第一作者：

第一作者机构： [1]Department of Neurology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, China. [2]Department of Neurology and Clinical Research Center of Neurological Disease, Second Affiliated Hospital of Soochow University, Suzhou, China. [3]Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, China.

通讯作者：

通讯机构： [2]Department of Neurology and Clinical Research Center of Neurological Disease, Second Affiliated Hospital of Soochow University, Suzhou, China. [3]Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, China. [5]Department of Neurology, Xiongan Xuanwu Hospital, Xiongan, China.

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