Risk prediction model of cognitive performance in older people with cardiovascular diseases: a study of the National Health and Nutrition Examination Survey database
机构:[1]Capital Med Univ, Xuanwu Hosp, Dept Vasc Surg, Beijing, Peoples R China首都医科大学宣武医院[2]Capital Med Univ, Xuanwu Hosp, Dept Intens Care Med, Beijing, Peoples R China首都医科大学宣武医院
Background and aim Changes in cognitive function are commonly associated with aging in patients with cardiovascular diseases. The objective of this research was to construct and validate a nomogram-based predictive model for the identification of cognitive impairment in older people suffering from cardiovascular diseases. Methods and results This retrospective study included 498 participants with cardiovascular diseases aged >60 selected from the NHANES 2011-2014. The study employed the Minor Absolute Shrinkage and Selection Operator (LASSO) regression model, in conjunction with multivariate logistic regression analysis, to identify relevant variables and develop a predictive model. We used statistical techniques as in the Minor Absolute Shrinkage (MAS) and the Selection Operator (LASSO) regression model, in conjunction with multivariate logistic regression analysis, to identify variables that were significantly predictive of the outcome. After which, based on the selected relevant variables, we developed a machine learning model that was predictive of cognitive impairment such as Alzheimer's diseases in the older people. The effectiveness of the resultant nomogram was evaluated by assessing its discriminative capability, calibration, and conducting decision curve analysis (DCA). The constructed predictive nomogram included age, race, educational attainment, poverty income ratio, and presence of sleep disorder as variables. The model demonstrated robust discriminative capability, achieving an area under the receiver-operating characteristic curve of 0.756, and exhibited precise calibration. Consistent performance was confirmed through 10-fold cross-validation, and DCA deemed the nomogram clinically valuable. Conclusion We constructed a NHANES cardiovascular-based nomogram predictive model of cognitive impairment. The model exhibited robust discriminative ability and validity, offering a scientific framework for community healthcare providers to assess and detect the risk of cognitive decline in these patients prematurely.
基金:
National Key Research and Development Program of China [2021YFC2500500]; Beijing Municipal Science & Technology Commission [Z241100009024028]
第一作者机构:[1]Capital Med Univ, Xuanwu Hosp, Dept Vasc Surg, Beijing, Peoples R China
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推荐引用方式(GB/T 7714):
Wang Hui,Wu Sensen,Pan Dikang,et al.Risk prediction model of cognitive performance in older people with cardiovascular diseases: a study of the National Health and Nutrition Examination Survey database[J].FRONTIERS IN PUBLIC HEALTH.2025,12:doi:10.3389/fpubh.2024.1447366.
APA:
Wang, Hui,Wu, Sensen,Pan, Dikang,Ning, Yachan,Wang, Cong...&Gu, Yongquan.(2025).Risk prediction model of cognitive performance in older people with cardiovascular diseases: a study of the National Health and Nutrition Examination Survey database.FRONTIERS IN PUBLIC HEALTH,12,
MLA:
Wang, Hui,et al."Risk prediction model of cognitive performance in older people with cardiovascular diseases: a study of the National Health and Nutrition Examination Survey database".FRONTIERS IN PUBLIC HEALTH 12.(2025)