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Risk prediction model of cognitive performance in older people with cardiovascular diseases: a study of the National Health and Nutrition Examination Survey database

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机构: [1]Capital Med Univ, Xuanwu Hosp, Dept Vasc Surg, Beijing, Peoples R China [2]Capital Med Univ, Xuanwu Hosp, Dept Intens Care Med, Beijing, Peoples R China
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关键词: cognitive impairment older adults Alzheimer's disease nomogram prediction model NHANES

摘要:
Background and aim Changes in cognitive function are commonly associated with aging in patients with cardiovascular diseases. The objective of this research was to construct and validate a nomogram-based predictive model for the identification of cognitive impairment in older people suffering from cardiovascular diseases. Methods and results This retrospective study included 498 participants with cardiovascular diseases aged >60 selected from the NHANES 2011-2014. The study employed the Minor Absolute Shrinkage and Selection Operator (LASSO) regression model, in conjunction with multivariate logistic regression analysis, to identify relevant variables and develop a predictive model. We used statistical techniques as in the Minor Absolute Shrinkage (MAS) and the Selection Operator (LASSO) regression model, in conjunction with multivariate logistic regression analysis, to identify variables that were significantly predictive of the outcome. After which, based on the selected relevant variables, we developed a machine learning model that was predictive of cognitive impairment such as Alzheimer's diseases in the older people. The effectiveness of the resultant nomogram was evaluated by assessing its discriminative capability, calibration, and conducting decision curve analysis (DCA). The constructed predictive nomogram included age, race, educational attainment, poverty income ratio, and presence of sleep disorder as variables. The model demonstrated robust discriminative capability, achieving an area under the receiver-operating characteristic curve of 0.756, and exhibited precise calibration. Consistent performance was confirmed through 10-fold cross-validation, and DCA deemed the nomogram clinically valuable. Conclusion We constructed a NHANES cardiovascular-based nomogram predictive model of cognitive impairment. The model exhibited robust discriminative ability and validity, offering a scientific framework for community healthcare providers to assess and detect the risk of cognitive decline in these patients prematurely.

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大类 | 3 区 医学
小类 | 3 区 公共卫生、环境卫生与职业卫生
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出版当年[2023]版:
Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
最新[2023]版:
Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

影响因子: 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

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第一作者机构: [1]Capital Med Univ, Xuanwu Hosp, Dept Vasc Surg, Beijing, Peoples R China
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