机构：[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.神经科系统神经外科首都医科大学宣武医院[2]Department of Neurosurgery, The Fourth Hospital of Changsha, Changsha, China.[3]Department of Neurology, Tangshan Central Hospital, Tangshan, China.[4]Department of Neurosurgery, Yangtze River Shipping General Hospital, Wuhan, China.[5]Pediatric Department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.[6]Department of Neurosurgery, Peking University Third Hospital, Beijing, China.
Neonatal brain injury due to bilirubin toxicity presents critical need for effective healing treatments. Docosahexaenoic acid (DHA), having neuroprotective properties, offers potential therapeutic benefits in promoting brain repair and recovery.This study focused on evaluating the healing capabilities of DHA in neonatal brains damaged by bilirubin-induced injury, with particular attention to its role in enhancing brain tissue repair mechanisms.Employing the bilirubin encephalopathy model in neonatal Sprague-Dawley rats and neuronal cell cultures, we investigated the therapeutic impact of DHA.The study measured improvements in brain tissue integrity, assessed bilirubin levels, analyzed gene and protein expressions pertinent to the brain's recovery process. DHA administration resulted in significant repair in neonatal brains, evidenced by reduction in bilirubin levels and restoration of normal brain tissue architecture.Molecular analysis indicated the distinct modulation of the CTBP1/miR-155-5p/KDM5A pathway, critical for cellular repair processes and marked decrease in markers of cellular damage and stress.
基金：
This work is supported by the National Natural Science Foundation of China (NSFC) (Grant Nos. 82171374, 81870945, 82001773).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类|4 区医学
小类|4 区妇产科学
第一作者：
第一作者机构：[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Shao Peng,Tang Yue,Li Yuxia,et al.Evaluating the healing effects of docosahexaenoic acid in neonates with bilirubin-induced brain injury[J].The Journal Of Maternal-Fetal & Neonatal Medicine : The Official Journal Of The European Association Of Perinatal Medicine, The Federation Of Asia And Oceania Perinatal Societies, The International Society Of Perinatal Obstetricians.2025,38(1):2467997.doi:10.1080/14767058.2025.2467997.
APA：
Shao Peng,Tang Yue,Li Yuxia,Zhang Jincan,Wang Jun...&Liu Peng.(2025).Evaluating the healing effects of docosahexaenoic acid in neonates with bilirubin-induced brain injury.The Journal Of Maternal-Fetal & Neonatal Medicine : The Official Journal Of The European Association Of Perinatal Medicine, The Federation Of Asia And Oceania Perinatal Societies, The International Society Of Perinatal Obstetricians,38,(1)
MLA：
Shao Peng,et al."Evaluating the healing effects of docosahexaenoic acid in neonates with bilirubin-induced brain injury".The Journal Of Maternal-Fetal & Neonatal Medicine : The Official Journal Of The European Association Of Perinatal Medicine, The Federation Of Asia And Oceania Perinatal Societies, The International Society Of Perinatal Obstetricians 38..1(2025):2467997
