The skeletal muscle is an important organ for movement and metabolism in human body, and its physiological aging underlies the occurrence of muscle atrophy and sarcopenia. China has the largest aging population in the world and is facing a grand challenge with how to prevent and treat skeletal muscle aging-related diseases. To address this difficult problem, the Aging Biomarker Consortium (ABC) of China has reached an expert consensus on biomarkers of skeletal muscle aging by synthesizing literatures and insights from scientists and clinicians. This consensus attempts to provide a comprehensive assessment of biomarkers associated with skeletal muscle aging, and proposes a systematic framework to classify them into three dimensions: functional, structural, and humoral. Within each dimension, the experts recommend clinically relevant biomarkers for skeletal muscle aging. This consensus aims to lay the foundation for future research on skeletal muscle aging, facilitating precise prediction, diagnosis, and treatment of skeletal muscle aging and sarcopenia. It is anticipated to make significant contributions to healthy aging of skeletal muscle in the elderly population in China and around the world as well.
基金：
National Natural Science Foundation of China (NSFC) (Nos. 92248304, 32400972, 82401845), Project of Max Cynader Academy of Brain Workstation, WCHSCU (No. HXYS19005),Sichuan Province science and technology innovation base project (No.2023ZYD0173), National Clinical Research Center for Geriatrics, West China Hospital (Nos. Z2024JC006, Z2023LC004), Sichuan Science and Technology Program (Nos. 2023NSFSC1158, 2024NSFSC1601,2024YFFK0099).
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验
第一作者：
第一作者机构：[1]Sichuan Univ, West China Hosp, Ctr Gerontol & Geriatr, Chengdu 610041, Peoples R China[2]Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Chengdu 610041, Peoples R China[3]Sichuan Univ, West China Hosp, Dept Geriatr, Chengdu 610041, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Sichuan Univ, West China Hosp, Ctr Gerontol & Geriatr, Chengdu 610041, Peoples R China[2]Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Chengdu 610041, Peoples R China[3]Sichuan Univ, West China Hosp, Dept Geriatr, Chengdu 610041, Peoples R China[4]Guangzhou Regenerat Med & Hlth, Bioland Lab, Guangdong Lab, Guangzhou 510005, Peoples R China[9]Chinese Acad Sci, Inst Zool, Key Lab Organ Regenerat & Reconstruct, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China[10]Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China[11]Univ Chinese Acad Sci, Beijing 100101, Peoples R China[12]Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China[13]Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China[14]Sichuan Real & Best Biotech Co Ltd, Chengdu 610041, Peoples R China[15]Nanjing Univ, Med Sch, Affiliated Hosp, Nanjing Drum Tower Hosp,Dept Spine Surg,State Key, Nanjing 210061, Peoples R China[16]Nanjing Univ, Med Sch, Affiliated Hosp, Nanjing Drum Tower Hosp,Dept Spine Surg,MOE,Key La, Nanjing 210061, Peoples R China[17]Shanghai Jiao Tong Univ, Sch Med, Spine Ctr, Xinhua Hosp, Shanghai 200072, Peoples R China[18]Guangzhou Lab, Guangzhou 510005, Peoples R China[19]Guangzhou Med Univ, Therapy & Rehabil Guangdong Higher Educ Inst, Key Lab Biol Targeting Diag, Affiliated Hosp 5, Guangzhou, Peoples R China[20]Affiliated Tongji Univ, Shanghai Tenth Peoples Hosp, Shanghai 200072, Peoples R China[22]Capital Med Univ, Xuanwu Hosp, Beijing Municipal Geriatr Med Res Ctr, Beijing 100053, Peoples R China[23]Capital Med Univ, Xuanwu Hosp, Aging Translat Med Ctr, Int Ctr Aging & Canc, Beijing 100053, Peoples R China[24]Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing Inst Brain Disorders, Beijing 100069, Peoples R China[25]Capital Med Univ, Natl Clin Res Ctr Geriatr Disorders, Xuanwu Hosp, Beijing 100053, Peoples R China[26]Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong 999077, Peoples R China[27]Chinese Univ Hong Kong, Prince Wales Hosp, Li Ka Shing Inst Hlth Sci, Hong Kong 999077, Peoples R China[31]Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China[32]Peking Union Med Coll, Sch Basic Med, Beijing 100005, Peoples R China[33]Sun Yat Sen Univ, Ctr Stem Cell Biol & Tissue Engn, Key Lab Stem Cells & Tissue Engn, Minist Educ, Guangzhou 510080, Peoples R China[34]Sun Yat Sen Univ, SYSU YSG Joint Lab Skin Hlth Res, Guangzhou 510080, Peoples R China[35]Sun Yat Sen Univ, Afiliated Hosp 1, Adv Med Technol Ctr, Zhongshan Sch Med, Guangzhou 510080, Peoples R China[36]Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genom & Precis Med, Beijing 100101, Peoples R China[37]China Natl Ctr Bioinformat, Beijing 100101, Peoples R China[40]Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan 430072, Peoples R China[41]Wuhan Univ, TaiKang Ctr Life & Med Sci, Wuhan 430072, Peoples R China[42]Wuhan Univ, Inst Adv Studies, Wuhan 430072, Peoples R China[43]Wuhan Univ, Frontier Sci Ctr Immunol & Metab, Wuhan 430072, Peoples R China
推荐引用方式(GB/T 7714)：
Huang Ning,Ge Meiling,Liu Xiaolei,et al.A framework of biomarkers for skeletal muscle aging: a consensus statement by the Aging Biomarker Consortium[J].LIFE MEDICINE.2025,3(6):doi:10.1093/lifemedi/lnaf001.
APA：
Huang, Ning,Ge, Meiling,Liu, Xiaolei,Tian, Xu,Yin, Pengbin...&Dong, Birong.(2025).A framework of biomarkers for skeletal muscle aging: a consensus statement by the Aging Biomarker Consortium.LIFE MEDICINE,3,(6)
MLA：
Huang, Ning,et al."A framework of biomarkers for skeletal muscle aging: a consensus statement by the Aging Biomarker Consortium".LIFE MEDICINE 3..6(2025)
