详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Decreased water exchange rate across the blood-brain barrier throughout the Alzheimer's disease continuum: Evidence from Chinese data

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. [2]Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. [3]Laboratory of FMRI Technology (LOFT), USC Mark &amp [4] Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [4]Department of Neurology, Xuan Wu Hospital of Capital Medical University, Beijing, China. [5]School of Biomedical Engineering, Hainan University, Haikou, China. [6]Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Gaoke Innovation Center, Shenzhen, China. [7]Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China. [8]National Clinical Research Center for Geriatric Diseases, Beijing, China. [9]The Central Hospital of Karamay, Karamay, China.

出处：

DOI：

ISSN：

关键词： Alzheimer’s disease biomarker blood–brain barrier magnetic resonance imaging plasma positron emission tomography water exchange rate

摘要：

Water exchange rate (Kw) across the blood-brain barrier (BBB) is used in magnetic resonance imaging (MRI) techniques to evaluate BBB functionality. Variations in BBB Kw across the Alzheimer's disease (AD) continuum remain uncertain.The study encompassed 38 cognitively normal individuals without AD biomarkers (CN_A-), 30 cognitively normal (CN_A+), and 31 cognitively impaired individuals (CI_A+) with positive AD biomarkers. Participants underwent clinical assessments, MRI/positron emission tomography scans, and assays of plasma biomarkers.Significantly lower Kw was observed in multiple brain regions throughout the AD continuum. This alteration in Kw correlated with plasma biomarkers and neuropsychological performance. Elevated levels of phosphorylated tau 217 intensified the inverse relationship between Kw and neuropsychological performance. The integration of Kw, brain volume, and plasma biomarkers demonstrated potential in distinguishing stages within the AD continuum.Consistently lower Kw was evident across the AD continuum and may act as a diagnostic tool for early AD screening.Observations revealed a decline in water exchange rate (Kw) across multiple brain regions within the Alzheimer's disease (AD) continuum, notably in the hippocampus, parahippocampal gyrus, and deep brain nuclei during the preclinical stage of AD. Strong correlations were established between Kw levels in various brain regions and plasma biomarkers, as well as neuropsychological performance in the AD continuum. Interaction between plasma phosphorylated tau (p-tau)217 and Kw in the hippocampus was linked to executive function, indicating a combined detrimental impact on cognitive abilities stemming from both blood-brain barrier Kw and p-tau 217. The combined use of Kw, brain volume, and plasma biomarkers-neurofilament light chain and glial fibrillary acidic protein-demonstrated potential for distinguishing individuals within the AD continuum.© 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2025]版：

大类 | 1 区

医学

小类 | 1 区临床神经病学

最新[2025]版：

大类 | 1 区

医学

小类 | 1 区临床神经病学

第一作者：

第一作者机构： [1]Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

共同第一作者：

通讯作者：

通讯机构： [4] Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [4]Department of Neurology, Xuan Wu Hospital of Capital Medical University, Beijing, China. [5]School of Biomedical Engineering, Hainan University, Haikou, China. [6]Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Gaoke Innovation Center, Shenzhen, China. [7]Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China. [8]National Clinical Research Center for Geriatric Diseases, Beijing, China. [9]The Central Hospital of Karamay, Karamay, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

Decreased water exchange rate across the blood-brain barrier throughout the Alzheimer's disease continuum: Evidence from Chinese data

文献详情

相关文献