机构：[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.神经科系统神经外科首都医科大学宣武医院[2]Department of Neurosurgery, China International Neuroscience Institute, Beijing 100053, China.[3]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.医技科室放射科首都医科大学宣武医院
Objectives: The objective of this study is to explore the potential variations in metabolic activity across gliomas originating from distinct cortical regions, as assessed by O-(2-18F-fluoroethyl)-L-tyrosine positron emission tomography (18F-FET PET). Also, this study seeks to elucidate whether these metabolic disparities correlate with the molecular characteristics and clinical prognoses of the tumors. Specifically, this research aims to determine whether variations in 18F-FET PET uptake are indicative of underlying genetic or biochemical differences that could influence patients' outcomes. Methods: The researchers retrospectively included 107 patients diagnosed with gliomas from neocortex and mesocortex, all of whom underwent hybrid PET/MR examinations, including 18F-FET PET and diffusion weighted imaging (DWI), prior to surgery. The mean and maximum tumor-to-background ratio (TBR) and apparent diffusion coefficient (ADC) values were calculated based on whole tumor volume segmentations. Comparisons of TBR, ADC values, and survival outcomes were performed to determine statistical differences between groups. Results: Among glioblastomas (GBMs, WHO grade 4) originating from the two cortical regions, there was a significant difference in the human Telomerase Reverse Transcriptase (TERT) promoter mutation rate, while no difference was observed in O6-Methylguanine-DNA Methyltransferase (MGMT) promoter methylation status. For WHO grade 3 gliomas, significant differences were found in the TERT promoter mutation rate and the proportion of 1p/19q co-deletion between the two cortical regions, whereas no difference was noted in MGMT methylation status. For WHO grade 2 gliomas, no molecular phenotypic differences were observed between the two cortical regions. In terms of survival, only GBMs originating from the mesocortex demonstrated significantly longer survival compared to those from the neocortex, while no statistically significant differences were found in survival for the other two groups. Conclusions: Gliomas originating from different cortical regions exhibit variations in metabolic activity, molecular phenotypes, and clinical outcomes.
基金：
This study has received funding from the National Key Research and Development Program
of China (No. 2022YFC2406905), the National Natural Science Foundation of China (No. 82373403 to
Y.C.), and the Beijing Natural Science Foundation (No. L222022).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|3 区医学
小类|3 区生化与分子生物学3 区医学：研究与实验3 区药学
最新[2025]版：
大类|3 区医学
小类|3 区生化与分子生物学3 区医学：研究与实验3 区药学
第一作者：
第一作者机构：[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.[2]Department of Neurosurgery, China International Neuroscience Institute, Beijing 100053, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.[2]Department of Neurosurgery, China International Neuroscience Institute, Beijing 100053, China.[3]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Diao Huantong,Wu Xiaolong,Li Xiaoran,et al.Cortical Origin-Dependent Metabolic and Molecular Heterogeneity in Gliomas: Insights from 18F-FET PET[J].Biomedicines.2025,13(3):doi:10.3390/biomedicines13030657.
APA：
Diao Huantong,Wu Xiaolong,Li Xiaoran,Liu Siheng,Shan Bingyang...&Tang Jie.(2025).Cortical Origin-Dependent Metabolic and Molecular Heterogeneity in Gliomas: Insights from 18F-FET PET.Biomedicines,13,(3)
MLA：
Diao Huantong,et al."Cortical Origin-Dependent Metabolic and Molecular Heterogeneity in Gliomas: Insights from 18F-FET PET".Biomedicines 13..3(2025)
