机构：[1]Beijing Institute of Brain Disorders, Capital Medical University, Beijing 100069, China[2]The George Institute for Global Health, University of New South Wales, Sydney 2000, Australia[3]Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing 100053, China神经科系统神经内科首都医科大学宣武医院[4]School of Statistics, University of Minnesota at Twin Cities, Minneapolis, MN 55455, USA[5]Department of Emergency, Xuanwu Hospital of Capital Medical University, Beijing 100053, China内科系统急诊科首都医科大学宣武医院[6]Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China神经科系统神经外科首都医科大学宣武医院[7]Department of Neurology and Stroke Center, Xuanwu Hospital of Capital Medical University, Beijing 100053, China神经科系统神经内科首都医科大学宣武医院[8]Department of Science and Technology, West China Hospital of Sichuan University, Chengdu 610041, China四川大学华西医院[9]Department of Ophthalmol‑ ogy, Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院[10]Department of Center for Clinical and Epidemiologic Research, Beijing Anzhen Hospital, Capital Medical University, Beijing 100013, China首都医科大学附属安贞医院[11]Department of Neurology, the First Afliated Hospital of Zhengzhou University, Zhengzhou 450002, China[12]Department of Neurology, the First Afliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China[13]Department of Neurosurgery, the First Afliated Hospital of Fujian Medical University, Fuzhou 350005, China[14]Department of Neurology, Ganzhou People’s Hospital, Ganzhou 341000, Jiangxi, China[15]Department of Neurology, the First Afliated Hospital of Guangxi Medical University, Xining 530021, China[16]Department of Neurology, the First Afliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China[17]Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300350, China[18]Department of Neurology, Shandong Provincial Hospital Afliated to Shandong First Medical University, Jinan 250021, China[19]Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan 750001, China[20]Department of Neurology, the First Afliated Hospital of USTC, Hefei 230001, China[21]Department of Neurol‑ ogy, Jining First People’s Hospital, Jining 272113, Shandong, China[22]Department of Neurology, Afliated Hospital of Nantong University, Nantong 226001, Jiangsu, China[23]Department of Neurology, Tangshan Gongren Hospital, Tangshan 063099, Hebei, China[24]Department of Neurology, the Second Afli‑ ated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China[25]Department of Neurology, Guizhou Provincial People’s Hospital, Guiyang 550002, China[26]Department of Neurology, Jiangxi Provincial People’s Hospital, Nanchang 330006, China[27]Department of Neurology, the First Peo‑ ple’s Hospital of Kashi, Kashi 84000, Xinjiang, China[28]Department of Neurol‑ ogy, Inner Mongolia People’s Hospital, Hohhot 010010, China[29]Department of Neurology, the Second Afliated Hospital of Anhui Medical University, Hefei 230601, China[30]Department of Neurology, the First Afliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China[31]Department of Neurology, Shanxi Provincial People’s Hospital, Taiyuan 030012, China[32]Department of Neurology, Baotou Central Hospital Inner Mongolia, Baotou 014040, Inner Mongolia Autonomous Region, China[33]Department of Neurology, Qujing No. 1 Hospital, Qujing 655000, Yunnan, China[34]Department of Neurology, Afliated Hospital of Zunyi Medical University, Zunyi 563099, Guizhou, China[35]Department of Neurology, Shengli Oilfeld Central Hospital, Dongy‑ ing 257100, Shandong, China[36]Department of Neurology, the First People’s Hospital of Chenzhou, Chenzhou 424300, Hunan, China[37]Institute of Science and Technology for Brain‑inspired Intelligence, Fudan University, Shang‑hai 200433, China.
BackgroundEndovascular treatment (EVT) is gaining popularity for the management of severe forms of cerebral venous thrombosis (CVT), but the evidence supporting its efficacy and safety is limited.MethodsThis multicenter study included patients with CVT admitted to 104 hospitals in 31 provinces/cities in China between January 2018 and June 2022. Propensity score weighting models were used to adjust baseline confounding variables to determine the association of EVT on the primary outcome of good functional status, defined as score 0 - 1 on the modified Rankin Scale after hospital discharge.ResultsOf 3063 patients identified through hospital records searches, 2774 adults [age (42 +/- 15.8) years, female 50.3%] fulfilled eligibility criteria and agreed to be included, of whom 449 (16.2%) received EVT and 2325 (83.8%) received standard care. There was no significant difference between the EVT group and the standard care group in terms of the possibility of good functional recovery [weighted risk ratio = 1.00, 95% confidence interval (CI) 0.96 - 1.03]. Similarly, there was no difference in the likelihood of death at hospital discharge (weighted risk ratio = 1.91, 95% CI 0.91 - 3.68). In subgroup analysis, the possibility of good functional recovery was lower in patients with intracerebral hemorrhage (weighted risk ratio = 0.88, 95% CI 0.79 - 0.98; P for interaction = 0.01) and seizures (weighted risk ratio = 0.86, 95% CI 0.76 - 0.95; P for interaction = 0.03).ConclusionIn this large nationwide study, EVT was not associated with improved functional outcomes compared to standard care in patients with CVT.
基金：
This work was supported by the Beijing Institute of Brain Disorders, the
National Natural Science Foundation of China (82171278), and the National
Health and Medical Research Council (NHMRC) of Australia (APP1195237).
第一作者机构：[1]Beijing Institute of Brain Disorders, Capital Medical University, Beijing 100069, China
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Institute of Brain Disorders, Capital Medical University, Beijing 100069, China[6]Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Bian He-Tao,Wang Xia,Liu Gui-You,et al.Endovascular treatment for cerebral venous thrombosis: a multicenter study in China[J].MILITARY MEDICAL RESEARCH.2025,12(1):doi:10.1186/s40779-025-00605-3.
APA：
Bian, He-Tao,Wang, Xia,Liu, Gui-You,Zhou, Chen,Meng, Ran...&Ji, Xun-Ming.(2025).Endovascular treatment for cerebral venous thrombosis: a multicenter study in China.MILITARY MEDICAL RESEARCH,12,(1)
MLA：
Bian, He-Tao,et al."Endovascular treatment for cerebral venous thrombosis: a multicenter study in China".MILITARY MEDICAL RESEARCH 12..1(2025)
医学