个人科研网厅 | | 帮助
首都医科大学宣武医院知识库
高级检索
当前位置： 首页 > 详情页

Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimers disease

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ 自然指数

作者：
Mengel, David[1,2,3] * ; Soter, Ester[1,2] ; Ott, Julia Maren[1,2] ; Wacker, Madeleine[1,2] ; Leyva, Alejandra[1,2] ; Peters, Oliver[4,5,6,7] ; Hellmann-Regen, Julian[4,6,8,9,10] ; Schneider, Luisa-Sophie[4,5,6,7,10,11] ; Wang, Xiao[6,8,9,10] ; Priller, Josef[4,12,13,14,15] ; Spruth, Eike[4,12] ; Altenstein, Slawek[4,12] ; Schneider, Anja[16,17] ; Fliessbach, Klaus[16,17] ; Wiltfang, Jens[18,19,20] ; Hansen, Niels[19] ; Rostamzadeh, Ayda[21,22] ; Duezel, Emra[23,24] ; Glanz, Wenzel[23] ; Incesoy, Enise I.[23,24,25] ; Buerger, Katharina[26,27] ; Janowitz, Daniel[26] ; Ewers, Michael[26,27] ; Perneczky, Robert[26,28,29,30] ; Rauchmann, Boris[28,31,32] ; Teipel, Stefan[33,34] ; Kilimann, Ingo[33,34] ; Laske, Christoph[3,35,36] ; Sodenkamp, Sebastian[3,37] ; Spottke, Annika[16,38] ; Brustkern, Johanna[16] ; Brosseron, Frederic[16] ; Wagner, Michael[16,39] ; Stark, Melina[16] ; Kleineidam, Luca[16,39] ; Shao, Kai[16,40] ; Luesebrink, Falk[33] ; Yakupov, Renat[33] ; Schmid, Matthias[16,41] ; Hetzer, Stefan[42] ; Dechent, Peter[43] ; Scheffler, Klaus[44] ; Berron, David[23,45] ; Jessen, Frank[16,21,22,46] ; Synofzik, Matthis[1,2,3] ;
机构： [1]Univ Tubingen, Div Translat Genom Neurodegenerat Dis, Hertie Inst Clin Brain Res, Hoppe Seyler Str 3, D-72076 Tubingen, Germany [2]Univ Tubingen, Ctr Neurol, Hoppe Seyler Str 3, D-72076 Tubingen, Germany [3]Univ Tubingen, German Ctr Neurodegenerat Dis DZNE, Otfried Muller Str 27, D-72076 Tubingen, Germany [4]German Ctr Neurodegenerat Dis DZNE, Robert Rossle Str 10, D-13125 Munich, Germany [5]Charite Univ Med Berlin, Charitepl 1, D-10117 Berlin, Germany [6]Free Univ Berlin, Charitepl 1, D-10117 Berlin, Germany [7]Humboldt Univ, Inst Psychiat & Psychotherapy, Charitepl 1, D-10117 Berlin, Germany [8]Charite Univ Med Berlin, Dept Psychiat, Charitepl 1, D-10117 Berlin, Germany [9]Humboldt Univ, Charitepl 1, D-10117 Berlin, Germany [10]German Ctr Mental Hlth DZPG, Partner Site Berlin, Charitepl 1, D-10117 Berlin, Germany [11]Charite Univ Med Berlin, Expt & Clin Res Ctr ECRC, Lindenberger Weg 80, D-13125 Berlin, Germany [12]Charite, Dept Psychiat & Psychotherapy, Charitepl 1, D-10117 Berlin, Germany [13]Tech Univ Munich, Sch Med, Dept Psychiat & Psychotherapy, Ismaninger Str 22, D-81675 Munich, Germany [14]Univ Edinburgh, Chancellors Bldg, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland [15]UK Dementia Res Inst UK DRI, Chancellors Bldg,49 Little France Crescent, Edinburgh EH16 4SB, Scotland [16]German Ctr Neurodegenerat Dis DZNE, Sigmund Freud Str 27, D-53127 Bonn, Germany [17]Univ Hosp Bonn, Dept Cognit Disorders & Old Age Psychiat, Sigmund Freud Str 25, D-53127 Bonn, Germany [18]German Ctr Neurodegenerat Dis DZNE, Von Siebold Str 3a, D-37075 Gottingen, Germany [19]Univ Gottingen, Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Von Siebold Str 3a, D-37075 Gottingen, Germany [20]Univ Aveiro, Inst Biomed IBiMED, Neurosci & Signaling Grp, Dept Med Sci, Campus Univ Santiago, P-3810193 Aveiro, Portugal [21]Univ Cologne, Fac Med, Dept Psychiat, Kerpener Str 62, D-50937 Cologne, Germany [22]Univ Cologne, Univ Hosp Cologne, Kerpener Str 62, D-50937 Cologne, Germany [23]German Ctr Neurodegenerat Dis DZNE, Leipziger Str 44, D-39120 Magdeburg, Germany [24]Otto von Guericke Univ, Inst Cognit Neurol & Dementia Res IKND, Leipziger Str 44, D-39120 Magdeburg, Germany [25]Univ Clin Magdeburg, Dept Psychiat & Psychotherapy, Leipziger Str 44, D-39120 Magdeburg, Germany [26]German Ctr Neurodegenerat Dis DZNE, Feodor Lynen Str 17, D-81377 Munich, Germany [27]LMU Munchen, Univ Hosp, Inst Stroke & Dementia Res ISD, Feodor Lynen Str 17, D-81377 Munich, Germany [28]LMU, Univ Hosp, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany [29]Munich Cluster Syst Neurol SyNergy, Feodor Lynen Str 17, D-81377 Munich, Germany [30]Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol Res Unit AGE, St Marys Campus,Norfolk Pl, London W2 1PG, England [31]Univ Sheffield, Sheffield Inst Translat Neurosci SITraN, 385a Glossop Rd, Sheffield S10 2HQ, England [32]Univ Hosp LMU, Dept Neuroradiol, Marchioninistr 15, D-81377 Munich, Germany [33]German Ctr Neurodegenerat Dis DZNE, Gehlsheimer Str 20, D-18147 Rostock, Germany [34]Rostock Univ, Med Ctr, Dept Psychosomat Med, Gehlsheimer Str 20, D-18147 Rostock, Germany [35]Univ Tubingen, Hertie Inst Clin Brain Res, Sect Dementia Res, Hoppe Seyler Str 3, D-72076 Tubingen, Germany [36]Univ Tubingen, Dept Psychiat & Psychotherapy, Hoppe Seyler Str 3, D-72076 Tubingen, Germany [37]Univ Tubingen, Dept Psychiat & Psychotherapy, Calwerstr 14, D-72076 Tubingen, Germany [38]Univ Bonn, Dept Neurol, Sigmund Freud Str 25, D-53127 Bonn, Germany [39]Univ Hosp Bonn, Dept Old Age Psychiat & Cognit Disorders, Sigmund Freud Str 25, D-53127 Bonn, Germany [40]Capital Med Univ, XuanWu Hosp, Dept Neurol, 45 Changchun St, Beijing 100053, Peoples R China [41]Univ Hosp Bonn, Inst Med Biometry, Sigmund Freud Str 25, D-53127 Bonn, Germany [42]Charite Univ Med Berlin, Berlin Ctr Adv Neuroimaging, Philippstr 13, D-10115 Berlin, Germany [43]Georg August Univ Gottingen, Dept Cognit Neurol, MR Res Neurosci, Von Siebold Str 3a, D-37075 Gottingen, Germany [44]Univ Tubingen, Dept Biomed Magnet Resonance, Hoppe Seyler Str 3, D-72076 Tubingen, Germany [45]Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Solvegatan 17, S-22362 Lund, Sweden [46]Univ Cologne, Excellence Cluster Cellular Stress Responses Aging, Joseph Stelzmann Str 26, D-50931 Cologne, Germany
出处：
DOI： 10.1038/s41380-025-03021-0
ISSN：

摘要：
Subjective cognitive decline (SCD) is proposed as an indicator of transitional disease stage 2 in the Alzheimer's disease (AD) continuum. However, molecular and particularly longitudinal fluid biomarker data for this stage are still limited. This study aimed to determine whether blood-based biomarkers in amyloid-positive individuals with SCD (A + SCD) support the notion of stage 2 as a distinct stage between stages 1 and 3 of AD and to identify those at high risk for clinical progression. In a prospective multicenter study (DELCODE) involving 457 participants across the AD continuum, we analyzed plasma phospho-tau 181 (p181) and neurofilament light chain (NfL) and assessed their association with longitudinal cognition, hippocampal atrophy, and AD clinical stage transition. The results showed that baseline plasma p181 levels were elevated and increased more rapidly in A + SCD individuals compared to amyloid-positive cognitively unimpaired (A + CU) individuals (stage 1). NfL levels rose across A + CU, A + SCD, and amyloid-positive mild cognitive impairment (A + MCI, stage 3). In A + SCD, but not in A + CU, higher p181 levels predicted cognitive decline (PACC5) and transition to MCI. In conclusion, plasma p181 provides molecular biomarker evidence supporting A + SCD as a pre-dementia AD stage (stage 2) distinct from A + CU (stage 1) and helps identify individuals at risk for cognitive decline early in the AD continuum.

基金：
The DELCODE study is funded by the German Center for Neurodegenerative Diseases (Deutsches Zentrum fr Neurodegenerative Erkrankungen, DZNE), reference number BN012. This work was additionally supported by the Clinician Scientist program "PRECISE.net
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 1 区 医学
小类 | 1 区 生化与分子生物学 1 区 神经科学 1 区 精神病学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 生化与分子生物学 1 区 神经科学 1 区 精神病学
JCR分区：
出版当年[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 NEUROSCIENCES Q1 PSYCHIATRY
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 NEUROSCIENCES Q1 PSYCHIATRY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Univ Tubingen, Div Translat Genom Neurodegenerat Dis, Hertie Inst Clin Brain Res, Hoppe Seyler Str 3, D-72076 Tubingen, Germany [2]Univ Tubingen, Ctr Neurol, Hoppe Seyler Str 3, D-72076 Tubingen, Germany [3]Univ Tubingen, German Ctr Neurodegenerat Dis DZNE, Otfried Muller Str 27, D-72076 Tubingen, Germany
通讯作者：
通讯机构： [1]Univ Tubingen, Div Translat Genom Neurodegenerat Dis, Hertie Inst Clin Brain Res, Hoppe Seyler Str 3, D-72076 Tubingen, Germany [2]Univ Tubingen, Ctr Neurol, Hoppe Seyler Str 3, D-72076 Tubingen, Germany [3]Univ Tubingen, German Ctr Neurodegenerat Dis DZNE, Otfried Muller Str 27, D-72076 Tubingen, Germany
推荐引用方式(GB/T 7714)：
Mengel David,Soter Ester,Ott Julia Maren,et al.Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer<acute accent>s disease[J].MOLECULAR PSYCHIATRY.2025,doi:10.1038/s41380-025-03021-0.
APA：
Mengel, David,Soter, Ester,Ott, Julia Maren,Wacker, Madeleine,Leyva, Alejandra...&Synofzik, Matthis.(2025).Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer<acute accent>s disease.MOLECULAR PSYCHIATRY,,
MLA：
Mengel, David,et al."Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer<acute accent>s disease".MOLECULAR PSYCHIATRY .(2025)

资源点击量：17292 今日访问量：0 总访问量：929 更新日期：2025-06-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持：重庆聚合科技有限公司 地址：北京市西城区长椿街45号宣武医院