Epidural hematomas (EDH), typically requiring surgery, may be managed conservatively in select patients. We investigated atorvastatin (10 mg/day) combined with dexamethasone (2.25 mg/day) as conservative therapy in six EDH patients (GCS >= 13, volume < 30 ml) post-trauma. All patients recovered fully without surgery, and literatures support conservative care for stable EDH. Our findings suggest this combination therapy may promote hematoma absorption. In conclusion, atorvastatin/dexamethasone shows promise as a non-surgical EDH option, warranting further investigation.
基金：
National Natural Science Foundation of China [82071390, 82271394, 82071402, 82171359, 82001323, 82101434]; Tianjin Key Medical Discipline (Specialty) Construction Project
第一作者机构：[1]Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China[2]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Neurosurg, Chengdu, Peoples R China[3]Tianjin Med Univ, Tianjin Neurol Inst,Gen Hosp, Dept Neurosurg,Tianjin & Minist Educ, State Key Lab Expt Hematol,Key Lab Postneuroinjury, Tianjin, Peoples R China
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推荐引用方式(GB/T 7714)：
Wu Chenrui,Tian Yu,Zhao Ruichen,et al.Conservative therapy of epidural hematoma with atorvastatin combined with glucocorticoids: cases report and literature review[J].FRONTIERS IN SURGERY.2025,12:doi:10.3389/fsurg.2025.1587988.
APA：
Wu, Chenrui,Tian, Yu,Zhao, Ruichen,Chen, Runfang,Xu, Chuanlin...&Jiang, Rongcai.(2025).Conservative therapy of epidural hematoma with atorvastatin combined with glucocorticoids: cases report and literature review.FRONTIERS IN SURGERY,12,
MLA：
Wu, Chenrui,et al."Conservative therapy of epidural hematoma with atorvastatin combined with glucocorticoids: cases report and literature review".FRONTIERS IN SURGERY 12.(2025)
