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Senescence-resistant human mesenchymal progenitor cells counter aging in primates

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机构: [1]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital Capital Medical University, Beijing 100053, China [2]State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [4]State Key Laboratory of Cognitive Science and Mental Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [5]Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China [6]Beijing Institute of Genomics, China National Center for Bioinformation, Chinese Academy of Sciences, Beijing 100101, China [7]International Center for Aging and Cancer, Hainan Medical University, Haikou 571199, China [8]College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China [9]University of Chinese Academy of Sciences, Beijing 100049, China [10]Sino-Danish College, Sino-Danish Centre for Education and Research, University of Chinese Academy of Sciences, Beijing 100049, China [11]Chongqing Fifth People’s Hospital, Chongqing 400060, China [12]Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-Sen University, Guangzhou 510060, China [13]Altos Labs San Diego Institute of Science, San Diego, CA, USA [14]Department of Neurosurgery, Beijing Municipal Geriatric Medical Research Center, National Medical Center for Neurological Diseases, Xuanwu Hospital Capital Medical University, Beijing 100053, China [15]Institute for Advanced Co-Creation Studies, The University of Osaka, Osaka 560-8531, Japan [16]Liver Transplant Center, Organ Transplant Center, West China Hospital of Sichuan University, Chengdu 610000, China [17]Laboratory of Liver Transplantation, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital of Sichuan University, Chengdu 610000, China [18]Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, Guangdong, China [19]National Clinical Research Center for Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China [20]Tissue Repair and Regeneration Research Center, Medical Innovation Department, PLA General Hospital and Medical College, Beijing 100842, China [21]Salk Institute for Biological Studies, La Jolla, CA 92037, USA [22]Aging Biomarker Consortium (ABC), Beijing 100101, China
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Aging is characterized by a deterioration of stem cell function, but the feasibility of replenishing these cells to counteract aging remains poorly defined. Our study addresses this gap by developing senescence (seno)-resistant human mesenchymal progenitor cells (SRCs), genetically fortified to enhance cellular resilience. In a 44-week trial, we intravenously delivered SRCs to aged macaques, noting a systemic reduction in aging indicators, such as cellular senescence, chronic inflammation, and tissue degeneration, without any detected adverse effects. Notably, SRC treatment enhanced brain architecture and cognitive function and alleviated the reproductive system decline. The restorative effects of SRCs are partly attributed to their exosomes, which combat cellular senescence. This study provides initial evidence that genetically modified human mesenchymal progenitors can slow primate aging, highlighting the therapeutic potential of regenerative approaches in combating age-related health decline.Copyright © 2025 Elsevier Inc. All rights reserved.

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大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
最新[2025]版:
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
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第一作者机构: [1]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital Capital Medical University, Beijing 100053, China
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通讯机构: [1]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital Capital Medical University, Beijing 100053, China [2]State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [5]Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China [9]University of Chinese Academy of Sciences, Beijing 100049, China [22]Aging Biomarker Consortium (ABC), Beijing 100101, China
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