(1) Background: Patients with mild cervical spondylotic myelopathy (CSM) who delay surgery risk progression. While PET evaluates spinal cord function, its cost and radiation limit its use. (2) Methods: In this prospective study, patients with mild cervical spondylosis underwent preoperative 18F-FDG PET-MRI. Narrowed spinal levels were classified based on whether SUVmax was decreased. Follow-up assessments were conducted. Two machine learning models using MRI T2-based radiomics were developed to identify stenotic levels and decreased SUVmax. (3) Results: Patients with normal SUVmax showed greater symptom improvement. The radiomics models performed well, with AUCs of 0.981/0.962 (training/testing) for stenosis detection and 0.830/0.812 for predicting SUVmax decline. The model outperformed clinicians in predicting SUVmax decline, improving the AUC by 10%. (4) Conclusion: Patients with preserved SUVmax have better outcomes. MRI-based radiomics shows potential for identifying stenosis and predicting spinal cord function changes for preoperative assessment, though larger studies are needed to validate its clinical utility.
基金：
This research was funded by the National Key R&D Program of China (2023YFC2507703).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|3 区医学
小类|3 区工程：生物医学
最新[2025]版：
大类|3 区医学
小类|3 区工程：生物医学
第一作者：
第一作者机构：[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun St, Xicheng District, Beijing 100053, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Wang He,Wang Kai,Wang Yutian,et al.MRI-Based Machine Learning and Radiomics Methods for Assessing Spinal Cord Function in Patients with Mild Cervical Spondylotic Myelopathy[J].Bioengineering (Basel, Switzerland).2025,12(6):doi:10.3390/bioengineering12060666.
APA：
Wang He,Wang Kai,Wang Yutian,Liu Zhenlei,Zhang Lei...&Wu Hao.(2025).MRI-Based Machine Learning and Radiomics Methods for Assessing Spinal Cord Function in Patients with Mild Cervical Spondylotic Myelopathy.Bioengineering (Basel, Switzerland),12,(6)
MLA：
Wang He,et al."MRI-Based Machine Learning and Radiomics Methods for Assessing Spinal Cord Function in Patients with Mild Cervical Spondylotic Myelopathy".Bioengineering (Basel, Switzerland) 12..6(2025)
