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Systematic profiling reveals betaine as an exercise mimetic for geroprotection

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机构: [1]Advanced Innovation Center for Human Brain Protection,National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital Capital Medical University, Beijing 100053,China [2]State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]China National Center for Bioinformation, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101,China [4]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [5]University of Chinese Academy of Sciences, Beijing 100049, China [6]CAS Key Laboratory of Pathogenic Microbioogy and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China [7]Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029,China [8]Department of Blood Transfusion,First Medical Center of ChinesePLA General Hospital, Beijing100853, China [9]International Center for Aging and Cancer, Hainan Academy of Medical Sciences, Hainan MedicalUniversity, Haikou 571199, Hainan, China [10]AItos Labs San Diego Institute of Science, San Diego, CA, USA [11]Department of Neurosurgery, NationalMedical Center for Neurological Diseases, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital Capital Medical University, Beijing 100053, China [12]Department of Urology, ChinesePLA General Hospital,PLA Medical School, Beijing 100853, China [13]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Laboratory, Beijing 100730, China [14]Tissue Repair and Regeneration Research Center, Medical Innovation Department,PLA General Hospitaland Medical College, Beijing 100842, China [15]Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [16]Salk Institute for Biological Studies, La Jolla, CA 92037, USA [17]Aging Biomarker Consortium (ABC), Beijing 100101, China
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Exercise has well-established health benefits, yet its molecular underpinnings remain incompletely understood. We conducted an integrated multi-omics analysis to compare the effects of acute vs. long-term exercise in healthy males. Acute exercise induced transient responses, whereas repeated exercise triggered adaptive changes, notably reducing cellular senescence and inflammation and enhancing betaine metabolism. Exercise-driven betaine enrichment, partly mediated by renal biosynthesis, exerts geroprotective effects and rescues age-related health decline in mice. Betaine binds to and inhibits TANK-binding kinase 1 (TBK1), retarding the kinetics of aging. These findings systematically elucidate the molecular benefits of exercise and position betaine as an exercise mimetic for healthy aging.Copyright © 2025 Elsevier Inc. All rights reserved.

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大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
最新[2025]版:
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
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第一作者机构: [1]Advanced Innovation Center for Human Brain Protection,National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital Capital Medical University, Beijing 100053,China
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通讯机构: [2]State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]China National Center for Bioinformation, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101,China [4]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [5]University of Chinese Academy of Sciences, Beijing 100049, China [7]Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029,China [15]Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [17]Aging Biomarker Consortium (ABC), Beijing 100101, China
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