机构：[a]Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China四川省人民医院[b]The Center of Clinical Diagnosis Laboratory, 302 Hospital of PLA, Beijing, China[c]Department of Laboratory Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China昆明医科大学附属第一医院[d]Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China[e]Center of Medical Laboratory, the General Hospital of Ningxia Medical University, Yinchuan, China[f]Department of Laboratory Medicine, The Traditional Chinese Medical Hospital of Guangdong, Guangzhou, Guangdong, China[g]Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China[h]Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA[i]Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1-harboring CRE strains have started to spread in different hospitals in China. In addition, this report presents the first description of chromosomal integration of mcr-1 into a carbapenem-resistant E. coli strain.
基金：
This study was supported by grants from the National Institutes of Health
(grants R01AI090155 and R21AI117338), National Natural Science Foundation
of China (grants 81572032, 81460322, and 81572058), and the
Chinese Military Medical and Technology Twelfth Five-Year Science and
Research Key Program Fund (grant BWS11C073).
第一作者机构：[a]Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China
共同第一作者：
通讯作者：
通讯机构：[g]Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China[h]Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
推荐引用方式(GB/T 7714)：
Hua Yu ,Fen Qu ,Bin Shan ,et al.Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China[J].ANTIMICROBIAL AGENTS AND CHEMOTHERAPY.2016,60(8):5033-5.doi:10.1128/AAC.00440-16.
APA：
Hua Yu,,Fen Qu,,Bin Shan,,Bin Huang,,Wei Jia,...&Liang Chen.(2016).Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,60,(8)
MLA：
Hua Yu,,et al."Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 60..8(2016):5033-5
医学