机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, No.1055, Sanxiang Road, Suzhou 215004, Jiangsu, China.[2]Department of Neurology, Changshu TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215000, China.[3]Centre for Big Data Research in Health, University of New South Wales, Sydney, NSW, Australia.[4]The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.[5]Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, China.[6]Department of Neurology, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215001, China.[7]Department of Neurology, Changshu First People’s Hospital, Suzhou 215500, China.[8]Institutes of Neuroscience, Soochow University, Suzhou 215123, China.
High white blood cell (WBC) count and high blood glucose level are risk factors for mortality and pneumonia after acute ischemic stroke (AIS). We investigated the combined effect of high WBC count and high blood glucose level on hospital admission and in-hospital mortality and pneumonia in acute AIS patients. A total of 3124 AIS patients enrolled from December 2013 to May 2014 across 22 hospitals in Suzhou city were included in the present study. We divided patients into four groups according to their level of WBC count and blood glucose: NWNG (normal WBC count and normal glucose), NWHG (normal WBC count and higher glucose), HWNG (higher WBC count and normal glucose), and HWHG (higher WBC count and higher glucose). Cox proportional hazard model and logistic regression model were used to estimate the combined effect of WBC count and blood glucose on all-cause in-hospital mortality and pneumonia in AIS patients. HWHG was associated with a 2.22-fold increase in the risk of in-hospital mortality in comparison to NWNG (adjusted hazard ratio [HR] 2.22; 95% confidence interval [CI], 1.21-4.07; P trend = 0.003). The risk of pneumonia was significantly higher in patients with HWHG compared to those with NWNG (adjusted odds ratio [OR] 2.61; 95% CI, 1.66-4.10; P trend < 0.001). The C-statistic for the combined WBC count and blood glucose was higher than WBC count or blood glucose alone for prediction of in-hospital mortality and pneumonia (all p < 0.01). High WBC count combined with high blood glucose level at admission was independently associated with in-hospital mortality and pneumonia in AIS patients. Moreover, the combination of WBC count and blood glucose level appeared to be a better predictor than WBC count or blood glucose alone.
基金：
National Natural Science Foundation of China [81471195]; Basic research of Suzhou Medical and health care [SYS201724]; Suzhou Clinical Research Center of Neurological Disease [Szzx201503]; Second Affiliated Hospital of Soochow University Preponderant Clinic Discipline Group Project Funding [XKQ2015002]; Suzhou health science and technology project [Gwzx201503]; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
第一作者机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, No.1055, Sanxiang Road, Suzhou 215004, Jiangsu, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, No.1055, Sanxiang Road, Suzhou 215004, Jiangsu, China.[8]Institutes of Neuroscience, Soochow University, Suzhou 215123, China.
推荐引用方式(GB/T 7714)：
Shoujiang You,Zhijie Ou,Wei Zhang,et al.Combined utility of white blood cell count and blood glucose for predicting in-hospital outcomes in acute ischemic stroke[J].JOURNAL OF NEUROINFLAMMATION.2019,16(1):37.doi:10.1186/s12974-019-1422-7.
APA：
Shoujiang You,Zhijie Ou,Wei Zhang,Danni Zheng,Chongke Zhong...&Chun-Feng Liu.(2019).Combined utility of white blood cell count and blood glucose for predicting in-hospital outcomes in acute ischemic stroke.JOURNAL OF NEUROINFLAMMATION,16,(1)
MLA：
Shoujiang You,et al."Combined utility of white blood cell count and blood glucose for predicting in-hospital outcomes in acute ischemic stroke".JOURNAL OF NEUROINFLAMMATION 16..1(2019):37
医学