机构：[a]Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China[b]Department of Neurology, Wenzhou People’s Hospital, Wenzhou, China[c]Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Aim of the study: Acute central nervous system viral infections are progressive and inflammatory diseases with inflammatory cells infiltrating into the central nervous system (CNS), and thyroid hormone (TH) level is associated with the oxidative and antioxidant status. Variations in oxidative stress and antioxidant status are related to the pathogenesis of inflammatory diseases. Our study aimed to investigate the possible correlation between viral infections in CNS and TH levels of thyroid stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3). Materials and methods: We measured serum concentrations of TSH, fT4, and fT3 in 206 individuals, including 59 viral meningitis (VM) patients, 60 viral encephalitis (VE) patients, and 87 healthy controls. Results: Our findings showed that VE and VM patients had lower levels of fT3 and higher levels of fT4 compared with healthy controls, whether male or female. Moreover, levels of TSH and fT3 in patients with viral infections in CNS were inversely correlated with disease prognosis measured by the Glasgow Outcome Scale. Conclusions: Variations in TH level may represent the oxidative status and are surrogate biomarkers for disease prognosis of acute central nervous system viral infections.
基金：
This study was supported by National Science Foundation of
Zhejiang (LY15H090019).
第一作者机构：[a]Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China[b]Department of Neurology, Wenzhou People’s Hospital, Wenzhou, China
通讯作者：
通讯机构：[*1]Department of Neurology, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215004, Jiangsu, China[*2]Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, 2 Fuxue Lane, Wenzhou 325000, Zhejiang, China
推荐引用方式(GB/T 7714)：
Qiaowen Tong,Weiwei Xiang,Hua Ye,et al.T3 level may be a helpful marker to predict disease prognosis of acute central nervous system viral infections[J].INTERNATIONAL JOURNAL OF NEUROSCIENCE.2019,129(2):139-145.doi:10.1080/00207454.2018.1510833.
APA：
Qiaowen Tong,Weiwei Xiang,Hua Ye,Hehui Zhang,Yiyi Chen...&Chunfeng Liu.(2019).T3 level may be a helpful marker to predict disease prognosis of acute central nervous system viral infections.INTERNATIONAL JOURNAL OF NEUROSCIENCE,129,(2)
MLA：
Qiaowen Tong,et al."T3 level may be a helpful marker to predict disease prognosis of acute central nervous system viral infections".INTERNATIONAL JOURNAL OF NEUROSCIENCE 129..2(2019):139-145
