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MicroRNA-433 inhibits cell growth and induces apoptosis in human cervical cancer through PI3K/AKT signaling by targeting FAK

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资源类型：

收录情况： ◇ SCIE

作者：
Xu, Jie[1] * ; Zhu, Weipei[1] ; Chen, Lijuan[1] ; Liu, Lili[1] ;
机构： [1]Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Suzhou University, Suzhou, Jiangsu 215000, P.R. China.
出处：
DOI： 10.3892/or.2018.6718
ISSN：

关键词： microRNA-433 cervical cancer focal adhesion kinase phosphoinositide 3-kinase AKT

摘要：
The present study aimed to examine the role of microRNA-433 in the growth and death of cervical cancer cells. RNA isolation, reverse transcription-quantitative polymerase chain reaction analysis, an MTT assay, flow cytometry, and western blot analysis were used for this investigation. The results showed that the expression of microRNA-433 was downregulated in patients with cervical cancer. The disease-free survival and overall survival rates of patients with low expression levels of microRNA-433 were lower, compared with those in patients with high expression levels of microRNA-433. The expression levels of microRNA-433 were downregulated in cervical cancer in vitro. It was found that the downregulation of microRNA-433 promoted the growth and inhibited the apoptosis of cervical cancer cells through activating focal adhesion kinase (FAK)/phosphoinositide 3-kinase (PI3K)/AKT signaling. However, the upregulation of microRNA-433 induced apoptosis and suppressed the growth of cervical cancer cells through inhibiting the FAK/PI3K/AKT signaling pathway. In addition, FAK or PI3K inhibitors promoted the death of cervical cancer cells following the downregulation of microRNA-433. These results revealed that microRNA-433 suppressed the growth of cervical cancer cells via the FAK/PI3K/AKT signaling pathway.

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 3 区 医学
小类 | 4 区 肿瘤学
最新[2023]版：
大类 | 3 区 医学
小类 | 4 区 肿瘤学
JCR分区：
出版当年[2016]版：
Q3 ONCOLOGY
最新[2023]版：
Q2 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [1]Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Suzhou University, Suzhou, Jiangsu 215000, P.R. China.
通讯作者：
通讯机构： [1]Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Suzhou University, Suzhou, Jiangsu 215000, P.R. China.
推荐引用方式(GB/T 7714)：
Xu Jie,Zhu Weipei,Chen Lijuan,et al.MicroRNA-433 inhibits cell growth and induces apoptosis in human cervical cancer through PI3K/AKT signaling by targeting FAK[J].ONCOLOGY REPORTS.2018,40(6):3469-3478.doi:10.3892/or.2018.6718.
APA：
Xu, Jie,Zhu, Weipei,Chen, Lijuan&Liu, Lili.(2018).MicroRNA-433 inhibits cell growth and induces apoptosis in human cervical cancer through PI3K/AKT signaling by targeting FAK.ONCOLOGY REPORTS,40,(6)
MLA：
Xu, Jie,et al."MicroRNA-433 inhibits cell growth and induces apoptosis in human cervical cancer through PI3K/AKT signaling by targeting FAK".ONCOLOGY REPORTS 40..6(2018):3469-3478

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