机构：[1]Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Rd, Suzhou 215004, China[2]Department of Neurosurgery, Clinical Medical College of Yangzhou University, 98 Nantong West-Road, Yangzhou 225001, China[3]Department of Pathology, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Rd, Suzhou 215004, China[4]Brain Tumor Lab, Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Soochow University, 1055 Sanxiang Rd, Suzhou 215004, China
Nucleolar and spindle-associated protein (NUSAP1) is a microtubule and chromatin-binding protein that stabilizes microtubules to prevent depolymerization, maintains spindle integrity. NUSAP1 could cross-link spindles into aster-like structures, networks and fibers. It has also been found to play roles in progression of several cancers. However, the potential correlation between NUSAP1 and clinical outcome in patients with glioblastoma multiforme (GBM) remains largely unknown. In the current study, we demonstrated that NUSAP1 was significantly up-regulated in GBM tissues compared with adult non-tumor brain tissues both in a validated cohort and a TCGA cohort. In addition, Kaplan-Meier analysis indicated that patients with high NUSAP1 expression had significantly lower OS (P=0.0027). Additionally, in the TCGA cohort, NUSAP1 expression was relatively lower in GBM patients within the neural and mesenchymal subtypes compared to other subtypes, and associated with the status of several genetic aberrations such as PTEN deletion and wild type IDH1. The present study provides new insights and evidence that NUSAP1 over-expression was significantly correlated with progression and prognosis of GBM. Furthermore, knockdown of NUSAP1 revealed its regulation on G2/M progression and cell proliferation (both in vitro and in vivo). These data demonstrate that NUSAP1 could serve as a novel prognostic biomarker and a potential therapeutic target for GBM.
基金：
This study was supported by National Natural Science
Foundation of China (81472739; 81602183; 81702457), Natural
Science Foundation of Jiangsu province, China (BK20151214).
第一作者机构：[1]Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Rd, Suzhou 215004, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Rd, Suzhou 215004, China[4]Brain Tumor Lab, Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Soochow University, 1055 Sanxiang Rd, Suzhou 215004, China
推荐引用方式(GB/T 7714)：
Zhiyuan Qian,Yuping Li,Jiawei Ma,et al.Prognostic value of NUSAP1 in progression and expansion of glioblastoma multiforme[J].JOURNAL OF NEURO-ONCOLOGY.2018,140(2):199-208.doi:10.1007/s11060-018-2942-1.
APA：
Zhiyuan Qian,Yuping Li,Jiawei Ma,Yanping Xue,Yujun Xi...&Jun Dong.(2018).Prognostic value of NUSAP1 in progression and expansion of glioblastoma multiforme.JOURNAL OF NEURO-ONCOLOGY,140,(2)
MLA：
Zhiyuan Qian,et al."Prognostic value of NUSAP1 in progression and expansion of glioblastoma multiforme".JOURNAL OF NEURO-ONCOLOGY 140..2(2018):199-208
