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The role of 5-hydroxymethylcytosine in mitochondria after ischemic stroke

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收录情况： ◇ SCIE

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机构： [1]Institute of Neuroscience, Soochow University, Suzhou City, China [2]Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou City, China [3]Department of Orthopedics, Clinical Medical College, Yangzhou University, Yangzhou City, China [4]Department of Orthopedics, Northern Jiangsu People’s Hospital, Yangzhou City, China

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关键词： ATP middle cerebral artery occlusion mitochondria Tet2 5-hydroxymethylcytosine

摘要：

5-Hydroxymethylcytosine (5hmC) exists in DNA, RNA, and mitochondrial DNA (mtDNA) and plays an important role in many diseases. Specifically, 5hmC is involved in promoting gene expression, and this process is regulated by Tet enzymes. In this study, we identified that there is no difference in male mice and female mice at first; then we examined the levels of 5hmC in mtDNA and explored the relationship among 5hmC, mitochondrial gene expression and ATP production after acute brain ischemia. The abundance of mtDNA 5hmC was increased at 1 d and peaked at 2 d after ischemic injury, whereas that of mtDNA 5mC was unchanged. Furthermore, increased mitochondrial Tet2 expression was found to be responsible for the increase in mtDNA 5hmC. Tet2 inhibition decreased the mtDNA 5hmC abundance and increased the ATP levels in mitochondria, suggesting an association between the cellular ATP levels and mtDNA 5hmC abundance. We also demonstrated that mtDNA 5hmC increased the mRNA levels of mitochondrial genes after ischemia/reperfusion (I/R) injury.

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出版当年[2017]版：

大类 | 3 区医学

小类 | 4 区神经科学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区神经科学

JCR分区：

出版当年[2016]版：

Q3 NEUROSCIENCES

最新[2023]版：

Q2 NEUROSCIENCES

影响因子： 2.9 最新[2023版] 4 最新五年平均 2.481 出版当年[2016版] 2.518 出版当年五年平均 2.689 出版前一年[2015版] 2.662 出版后一年[2017版]

第一作者：

第一作者机构： [1]Institute of Neuroscience, Soochow University, Suzhou City, China

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通讯作者：

通讯机构： [*1]Department of Orthopedics, Clinical Medical College, Yangzhou University, Yangzhou City, China [*2]Department of Orthopedics, Northern Jiangsu People’s Hospital, Yangzhou City, China [*3]Institute of Neuroscience, Soochow University, 199 Ren-Ai Road, Suzhou City, Jiangsu Province, China

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