机构：[1]Department of Radiotherapy and Oncology, the Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Suzhou, Jiangsu, China,[2]Department of Radiotherapy and Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China,[3]Department of Oncology, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
CIP2A, cancerous inhibitor of protein phosphatase 2A, was initially recognized as an oncoprotein. Recently several studies revealed that CIP2A could function as a prognosis bio-marker, however, the result remained not comprehensive, partly due to small number of patients included individually. Here we carried out a meta-analysis of published studies to assess the prognostic significance of CIP2A in solid tumors. All eligible studies were identified through searching PubMed, Embase and Web of Science database. In this meta-analysis, 22 studies involving 4,579 participants were included, and we verified that CIP2A over-expression was significantly related with poor overall survival (pooled HR = 1.844, 95% CI = 1.528-2.225, P<0.001) and short disease free survival (pooled HR = 1.808, 95% CI = 1.591-2.055, P<0.001) in solid tumors. Additionally, subgroup analysis suggested that the trend of a poor overall survival with an increased CIP2A expression was present in East-Asian and European patients, as well as in lung cancer and colorectal cancer. To sum up, CIP2A over-expression was associated with poor survival in human solid tumors and might be a predictive factor of poor prognosis.
基金：
National Natural Science Foundation
81472786 and 81773192, Natural Science
Foundation of Jiangsu Province BK20171248,
Jiangsu Province Youth Medical Talents Project,
QNRC2016527, the Foundation of tumor clinical
and basic research team KYC005, and Suzhou City
Health Science and Technology Project
LCZX201619 to MBC.
第一作者机构：[1]Department of Radiotherapy and Oncology, the Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Suzhou, Jiangsu, China,[2]Department of Radiotherapy and Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Radiotherapy and Oncology, the Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Suzhou, Jiangsu, China,
推荐引用方式(GB/T 7714)：
Min Tang,Jiao-Feng Shen,Ping Li,et al.Prognostic significance of CIP2A expression in solid tumors: A meta-analysis[J].PLOS ONE.2018,13(7):e0199675.doi:10.1371/journal.pone.0199675.
APA：
Min Tang,Jiao-Feng Shen,Ping Li,Li-Na Zhou,Ping Zeng...&Ye Tian.(2018).Prognostic significance of CIP2A expression in solid tumors: A meta-analysis.PLOS ONE,13,(7)
MLA：
Min Tang,et al."Prognostic significance of CIP2A expression in solid tumors: A meta-analysis".PLOS ONE 13..7(2018):e0199675
