机构：[1]Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China[2]Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
Light as an external stimulus can be precisely manipulated in terms of irradiation time, site, wavelength, and density. As such, photoresponsive drug/gene delivery systems have been increasingly pursued and utilized for the spatiotemporal control of drug/gene delivery to enhance their therapeutic efficacy and safety. In this review, we summarized the recent research progress on photoresponsive drug/gene delivery, and two major categories of delivery systems were discussed. The first category is the direct responsive systems that experience photoreactions on the vehicle or drug themselves, and different materials as well as chemical structures responsive to UV, visible, and NIR light are summarized. The second category is the indirect responsive systems that require a light-generated mediator signal, such as heat, ROS, hypoxia, and gas molecules, to cascadingly trigger the structural transformation. The future outlook and challenges are also discussed at the end.
基金：
The authors acknowledge financial support from the National
Natural Science Foundation of China (51573123 and
51722305), the Ministry of Science and Technology of China
(2016YFA0201200), and Priority Academic Program Development
of Jiangsu Higher Education Institutions (PAPD).
第一作者机构：[1]Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China
共同第一作者：
通讯作者：
通讯机构：[1]Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China
推荐引用方式(GB/T 7714)：
Yang Zhou ,Huan Ye ,Yongbing Chen,et al.Photoresponsive Drug/Gene Delivery Systems[J].BIOMACROMOLECULES.2018,19(6):1840-1857.doi:10.1021/acs.biomac.8b00422.
APA：
Yang Zhou,,Huan Ye,,Yongbing Chen,Rongying Zhu&Lichen Yin.(2018).Photoresponsive Drug/Gene Delivery Systems.BIOMACROMOLECULES,19,(6)
MLA：
Yang Zhou,,et al."Photoresponsive Drug/Gene Delivery Systems".BIOMACROMOLECULES 19..6(2018):1840-1857
化学