机构:[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China[2]Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China
Objective: Excessive daytime sleepiness (EDS) is one of the most common sleep abnormalities in patients with Parkinson's disease (PD), yet its multifactorial etiology complicates its treatment. This review summarized recent studies on the epidemiology, etiology, clinical implications, associated features, and evaluation of EDS in PD. The efficacy of pharmacologic and non-pharmacologic treatments for EDS in PD was also reviewed. Data Sources: English language articles indexed in PubMed and Cochrane databases and Chinese-language papers indexed in Wanfang and National Knowledge Infrastructure databases that were published between January 1987 and November 2017 were located using the following search terms: "sleepiness", "sleep and Parkinson's disease", and "Parkinson's disease and treatment". Study Selection: Original research articles and critical reviews related to EDS in PD were selected. Results: EDS is a major health hazard and is associated with many motor and nonmotor symptoms of PD. Its causes are multifactorial. There are few specific guidelines for the treatment of EDS in PD. It is first necessary to identify and treat any possible factors causing EDS. Recent studies showed that some nonpharmacologic (i.e., cognitive behavioral therapy, light therapy, and repetitive transcranial magnetic stimulation) and pharmacologic (i.e., modafinil, methylphenidate, caffeine, istradefylline, sodium oxybate, and atomoxetine) treatments may be effective in treating EDS in PD. Conclusions: EDS is common in the PD population and can have an immensely negative impact on quality of life. Its causes are multifactorial, which complicates its treatment. Further investigations are required to determine the safety and efficacy of potential therapies and to develop novel treatment approaches for EDS in PD.
基金:
This work was supported by grants from the National Key
R&D Program of China (No. 2017YFC0909100), National
Natural Science Foundation of China (No. 91649114),
Jiangsu Provincial Social Development Projects
(No. BE2017653), Jiangsu Provincial Medical Key
Discipline Project (No. ZDXKB2016022), Jiangsu Key
Laboratory of Neuropsychiatric Diseases (No. BM2013003),
and Suzhou Clinical Research Center of Neurological
Disease (No. Szzx201503). This work was also partly
supported by grants from the Suzhou Youth Technology
Project Foundation (No. KJXW2016014) and Priority
Academic Program Development of Jiangsu Higher
Education Institutions.
第一作者机构:[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China
通讯作者:
通讯机构:[*1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu 215004, China
推荐引用方式(GB/T 7714):
Yun Shen,Jun-Ying Huang,Jie Li,et al.Excessive Daytime Sleepiness in Parkinson's Disease: Clinical Implications and Management[J].CHINESE MEDICAL JOURNAL.2018,131(8):974-981.doi:10.4103/0366-6999.229889.
APA:
Yun Shen,Jun-Ying Huang,Jie Li&Chun-Feng Liu.(2018).Excessive Daytime Sleepiness in Parkinson's Disease: Clinical Implications and Management.CHINESE MEDICAL JOURNAL,131,(8)
MLA:
Yun Shen,et al."Excessive Daytime Sleepiness in Parkinson's Disease: Clinical Implications and Management".CHINESE MEDICAL JOURNAL 131..8(2018):974-981