机构：[a]Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, P.R. China[b]Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, P.R. China
Background: The prognostic value of White Blood Cell (WBC) counts and C-reactive Protein (CRP) in clinical outcomes of Acute Ischemic Stroke (AIS) patients after Intravenous Thrombolysis (IVT) remains unknown. We investigated the association of WBC counts and CRP with 3-month functional outcomes and all-cause mortality in AIS patients. Methods: 447 AIS patients treated with IVT between May 2010 and May 2017 were enrolled. WBC counts and CRP were measured within 24 hours after IVT. The main outcomes included poor functional outcomes (modified Rankin score >= 3) at 3 months and 3-month all-cause mortality. Results: High WBC counts were associated with poor functional outcomes (adjusted OR (odds ratio) 4.48; 95% CI (confidence interval) 2.00-10.03; P-trend<0.001) and with all-cause mortality (adjusted HR (hazard ratio) 2.19; 95% CI 1.07-4.49; P-trend=0.018). In addition, high CRP levels were associated with poor functional outcomes (adjusted OR 4.95; 95% CI 1.39-17.65; P-trend=0.002). However, no significant association between high CRP levels and all-cause mortality was observed (adjusted HR 2.61; 95% CI 0.80-8.47; P-trend=0.138). Conclusion: Our analysis indicated that elevated WBC counts and CRP levels after IVT can independently predict poor outcome among AIS patients.
基金：
This work was supported by Suzhou Clinical Research
Center of Neurological Disease [grant number szzx201503],
the Priority Academic Program Development of Jiangsu
Higher Education Institutions, and the Suzhou Youth Science
and Technology Project [grant number
KJXW2015010].
第一作者机构：[a]Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, P.R. China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China[*2]Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, 215004, China
推荐引用方式(GB/T 7714)：
Xinyuan Qu,Jijun Shi,Yongjun Cao,et al.Prognostic Value of White Blood Cell Counts and C-reactive Protein in Acute Ischemic Stroke Patients after Intravenous Thrombolysis[J].CURRENT NEUROVASCULAR RESEARCH.2018,15(1):10-17.doi:10.2174/1567202615666180326101524.
APA：
Xinyuan Qu,Jijun Shi,Yongjun Cao,Mingzhi Zhang&Jiaping Xu.(2018).Prognostic Value of White Blood Cell Counts and C-reactive Protein in Acute Ischemic Stroke Patients after Intravenous Thrombolysis.CURRENT NEUROVASCULAR RESEARCH,15,(1)
MLA：
Xinyuan Qu,et al."Prognostic Value of White Blood Cell Counts and C-reactive Protein in Acute Ischemic Stroke Patients after Intravenous Thrombolysis".CURRENT NEUROVASCULAR RESEARCH 15..1(2018):10-17
